Tyr497
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr497  -  EPS8 (mouse)

Site Information
yAySSSMyHRGPHAD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450735

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Brk (mouse) ( 1 )
Kinases, in vitro:
Brk (mouse) ( 1 )
Treatments:
EGF ( 1 )

Downstream Regulation
Effects of modification on EPS8:
phosphorylation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell adhesion, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 )

References 

1

Shin WS, et al. (2017) PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8. J Cell Biochem 118, 2887-2895
28214294   Curated Info

2

Moritz A (2003) CST Curation Set: 156; Year: 2003; Biosample/Treatment: cell line, 3T3/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info