Ser262
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser262  -  GJA1 (mouse)

Site Information
sPskDCGsPkyAyFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450694

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 6 , 8 ) , microscopy-colocalization with upstream kinase ( 4 ) , phospho-antibody ( 3 , 4 , 9 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
brain ( 6 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 8 ) , ovary ( 4 , 9 ) , TM4 (sertoli) ( 3 )

Upstream Regulation
Treatments:
benzo(a)pyrene ( 3 ) , LH ( 9 ) , U0124 ( 9 ) , U0126 ( 9 )

References 

1

Solan JL, Marquez-Rosado L, Lampe PD (2019) Cx43 phosphorylation mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter stability of stress-inducible protein NDRG1. J Biol Chem
31189653   Curated Info

2

Sun Z, et al. (2019) Connexin 43-serine 282 modulates serine 279 phosphorylation in cardiomyocytes. Biochem Biophys Res Commun 513, 567-572
30981509   Curated Info

3

Ji X, et al. (2018) Benzo[a]pyrene-decreased gap junctional intercellular communication via calcium/calmodulin signaling increases apoptosis in TM4 cells. J Appl Toxicol
29578247   Curated Info

4

Norris RP, Baena V, Terasaki M (2017) Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy. J Cell Sci 130, 1333-1340
28202692   Curated Info

5

Kang M, et al. (2014) Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. Cell Commun Signal 12, 58
25262337   Curated Info

6

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

7

Dyce PW, Norris RP, Lampe PD, Kidder GM (2012) Phosphorylation of Serine Residues in the C-terminal Cytoplasmic Tail of Connexin43 Regulates Proliferation of Ovarian Granulosa Cells. J Membr Biol 245, 291-301
22729691   Curated Info

8

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

9

Norris RP, et al. (2008) Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development 135, 3229-38
18776144   Curated Info