Ser262
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Home > Phosphorylation Site Page: > Ser262  -  GJA1 (mouse)

Site Information
sPskDCGsPkyAyFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450694

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 7 , 9 , 10 ) , microscopy-colocalization with upstream kinase ( 5 ) , mutation of modification site ( 3 , 8 ) , phospho-antibody ( 1 , 2 , 4 , 5 , 6 , 11 ) , western blotting ( 1 , 2 , 4 , 6 )
Relevant cell line - cell type - tissue:
'heart, ventricle' ( 6 ) , brain ( 3 , 7 ) , heart ( 1 , 10 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 9 ) , myocyte-heart ( 2 , 6 ) , oocyte ( 8 ) , ovary ( 5 , 8 , 11 ) , TM4 (sertoli) ( 4 )

Upstream Regulation
Treatments:
2-APB ( 6 ) , ATP ( 6 ) , benzo(a)pyrene ( 4 ) , LH ( 11 ) , U0124 ( 11 ) , U0126 ( 11 ) , XeC ( 6 )

References 

1

Solan JL, Marquez-Rosado L, Lampe PD (2019) Cx43 phosphorylation mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter stability of stress-inducible protein NDRG1. J Biol Chem
31189653   Curated Info

2

Sun Z, et al. (2019) Connexin 43-serine 282 modulates serine 279 phosphorylation in cardiomyocytes. Biochem Biophys Res Commun 513, 567-572
30981509   Curated Info

3

Freitas-Andrade M, et al. (2019) Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke. J Exp Med 216, 916-935
30872361   Curated Info

4

Ji X, et al. (2018) Benzo[a]pyrene-decreased gap junctional intercellular communication via calcium/calmodulin signaling increases apoptosis in TM4 cells. J Appl Toxicol
29578247   Curated Info

5

Norris RP, Baena V, Terasaki M (2017) Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy. J Cell Sci 130, 1333-1340
28202692   Curated Info

6

Kang M, et al. (2014) Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. Cell Commun Signal 12, 58
25262337   Curated Info

7

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

8

Dyce PW, Norris RP, Lampe PD, Kidder GM (2012) Phosphorylation of Serine Residues in the C-terminal Cytoplasmic Tail of Connexin43 Regulates Proliferation of Ovarian Granulosa Cells. J Membr Biol 245, 291-301
22729691   Curated Info

9

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

10

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

11

Norris RP, et al. (2008) Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development 135, 3229-38
18776144   Curated Info