Ser262
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Home > Phosphorylation Site Page: > Ser262  -  GJA1 (rat)

Site Information
sPskDCGsPkyAyFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450694

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 8 ) , mutation of modification site ( 5 , 7 , 9 ) , phospho-antibody ( 7 , 9 , 10 ) , western blotting ( 7 , 10 )
Relevant cell line - cell type - tissue:
'heart, embryo' ( 7 ) , heart ( 8 , 10 ) , myocyte-heart ( 9 ) , oocyte ( 5 )

Upstream Regulation
Putative in vivo kinases:
PKCA (rat) ( 9 )
Treatments:
FGF2 ( 4 , 7 , 9 , 10 ) , ischemia ( 7 ) , phorbol_ester ( 3 , 9 ) , PKCE_inhibitor ( 3 ) , TGF-beta ( 4 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, altered ( 9 )

References 

1

Yang Y, et al. (2019) Connexin43 dephosphorylation at serine 282 is associated with connexin43-mediated cardiomyocyte apoptosis. Cell Death Differ
30770876   Curated Info

2

Kang M, et al. (2014) Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. Cell Commun Signal 12, 58
25262337   Curated Info

3

Srisakuldee W, et al. (2014) The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent. Cardiovasc Res 103, 72-80
24654232   Curated Info

4

Jeyaraman MM, Fandrich RR, Kardami E (2013) Together and apart: inhibition of DNA synthesis by connexin-43 and its relationship to transforming growth factor β. Front Pharmacol 4, 90
23882217   Curated Info

5

Mitra SS, Xu J, Nicholson BJ (2012) Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels. J Membr Biol 245, 495-506
22965738   Curated Info

6

Xu HJ, et al. (2012) S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 31, 663-9
22608771   Curated Info

7

Srisakuldee W, et al. (2009) Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state. Cardiovasc Res 83, 672-81
19423616   Curated Info

8

Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8
16678851   Curated Info

9

Doble BW, et al. (2004) Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J Cell Sci 117, 507-14
14702389   Curated Info

10

Srisakuldee W, et al. Administration of FGF-2 to the heart stimulates connexin-43 phosphorylation at protein kinase C target sites. Cell Commun Adhes 13, 13-9
16613776   Curated Info