Ser42
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Home > Phosphorylation Site Page: > Ser42  -  TNNI3 (human)

Site Information
AKKKskIsAsRKLQL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450690

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , heart ( 3 ) , myocyte-heart ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 2 , 5 )

Downstream Regulation
Effects of modification on TNNI3:
activity, inhibited ( 2 ) , molecular association, regulation ( 5 )
Inhibit interaction with:
TNNC1 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
DCM ( 3 )

References 

1

Liu B, Lopez JJ, Biesiadecki BJ, Davis JP (2014) Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. PLoS One 9, e86279
24466001   Curated Info

2

Kooij V, et al. (2013) PKCĪ±-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis. PLoS One 8, e74847
24116014   Curated Info

3

Zhang P, et al. (2012) Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart. Circulation 126, 1828-37
22972900   Curated Info

4

Oliveira SM, et al. (2012) AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circ Res 110, 1192-201
22456184   Curated Info

5

Ward DG, et al. (2004) NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I. Biochemistry 43, 5772-81
15134451   Curated Info