Ser529
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Home > Phosphorylation Site Page: > Ser529  -  ANPA (human)

Site Information
RHLRSAGsRLtLsGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447512

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 3 )

Downstream Regulation
Effects of modification on ANPA:
activity, induced ( 3 ) , enzymatic activity, induced ( 1 )

References 

1

Otto NM, McDowell WG, Dickey DM, Potter LR (2017) A Glutamate-Substituted Mutant Mimics the Phosphorylated and Active Form of Guanylyl Cyclase-A. Mol Pharmacol 92, 67-74
28416574   Curated Info

2

Yoder AR, Stone MD, Griffin TJ, Potter LR (2010) Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B. Biochemistry 49, 10137-45
20977274   Curated Info

3

Potter LR, Hunter T (1998) Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. Mol Cell Biol 18, 2164-72
9528788   Curated Info

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