Thr40
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Home > Phosphorylation Site Page: > Thr40  -  SOD1 (human)

Site Information
WGsIkGLtEGLHGFH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1100571300

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 2 ) , liver cancer ( 2 ) , hepatocellular carcinoma ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , HEK293T (epithelial) ( 2 ) , Hep 3B2.1-7 (hepatic) ( 2 ) , MCF-7 (breast cell) ( 2 )

Upstream Regulation
Kinases, in vitro:
mTOR (human) ( 2 )
Treatments:
glucose_starvation ( 2 )

Downstream Regulation
Effects of modification on SOD1:
enzymatic activity, inhibited ( 1 , 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 2 )

References 

1

Norambuena A, et al. (2022) SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers. Neurobiol Dis 169, 105737
35452786   Curated Info

2

Tsang CK, et al. (2018) SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell 70, 502-515.e8
29727620   Curated Info

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