Ser251
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Home > Phosphorylation Site Page: > Ser251  -  FOXM1 iso2 (human)

Site Information
MIQFAINstERKRMT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10897608

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
U2OS (bone cell) [PLK1 (human), transfection] ( 1 )

Upstream Regulation
Regulatory protein:
PLK1 (human) ( 1 )

Downstream Regulation
Effects of modification on FOXM1 iso2:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
CBP (human) ( 1 )

References 

1

Chen YJ, et al. (2009) A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem 284, 30695-707
19737929   Curated Info

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