Ser40
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Home > Phosphorylation Site Page: > Ser40  -  TH iso3 (human)

Site Information
RFIGRRQsLIEDARK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448545

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , phospho-antibody ( 1 , 2 , 4 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 6 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 ) , brain cancer ( 6 ) , glioblastoma ( 6 ) , glioma ( 6 ) , neuroblastoma ( 2 , 4 )
Relevant cell line - cell type - tissue:
'neuron, cerebellar granule'-brain ( 6 ) , 293 (epithelial) ( 2 ) , adrenal gland ( 6 ) , adrenal medulla ( 1 ) , BE(2)-C (glial) ( 6 ) , E.coli (bacterial) ( 3 ) , PC-12 (chromaffin) ( 2 ) , SH-SY5Y (neural crest) ( 2 , 4 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
CAMK2A (human) ( 5 ) , CAMK2A (rat) ( 9 , 10 ) , MAPKAPK2 (human) ( 7 , 10 ) , MAPKAPK5 (human) ( 7 ) , MSK1 (human) ( 7 ) , PKACA (cow) ( 9 , 10 ) , PKACA (human) ( 3 , 5 ) , RSK2 (human) ( 10 )
Treatments:
8-Rp-cAMP ( 6 ) , ACh ( 1 ) , colforsin ( 4 ) , EGF ( 4 ) , GDNF ( 6 ) , H-89 ( 1 ) , muscarine ( 4 ) , PD98059 ( 6 ) , serum_starvation ( 6 ) , Shenmai ( 1 ) , U0126 ( 4 )

Downstream Regulation
Effects of modification on TH iso3:
enzymatic activity, induced ( 1 , 7 , 8 , 10 )

Disease / Diagnostics Relevance
Relevant diseases:
PSP ( 8 )

References 

1

Zhang X, et al. (2020) The Inhibition Effects of Shenmai Injection on Acetylcholine-Induced Catecholamine Synthesis and Secretion by Modulating Nicotinic Acetylcholine Receptor Ion Channels in Cultured Bovine Adrenal Medullary Cells. Evid Based Complement Alternat Med 2020, 8514926
33456492   Curated Info

2

Jorge-Finnigan A, et al. (2017) Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. J Biol Chem 292, 14092-14107
28637871   Curated Info

3

Kleppe R, et al. (2014) Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Mol Cell Proteomics 13, 2017-30
24947669   Curated Info

4

Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW (2009) Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35. Biochim Biophys Acta 1793, 1860-7
19833152   Curated Info

5

Lehmann IT, et al. (2006) Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J Biol Chem 281, 17644-51
16644734   Curated Info

6

Kobori N, et al. (2004) Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor. J Biol Chem 279, 2182-91
14570886   Curated Info

7

Toska K, et al. (2002) Regulation of tyrosine hydroxylase by stress-activated protein kinases. J Neurochem 83, 775-83
12421349   Curated Info

8

Bodeau-Péan S, et al. (1999) A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity. J Biol Chem 274, 3469-75
9920892   Curated Info

9

Alterio J, et al. (1998) Human tyrosine hydroxylase isoforms. Inhibition by excess tetrahydropterin and unusual behavior of isoform 3 after camp-dependent protein kinase phosphorylation. J Biol Chem 273, 10196-201
9553069   Curated Info

10

Sutherland C, et al. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. Eur J Biochem 217, 715-22
7901013   Curated Info

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