Tyr1592
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Home > Phosphorylation Site Page: > Tyr1592  -  ALK (mouse)

Site Information
CGNVNYGyQQQGLPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450381

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, sympathetic' ( 1 ) , IMR32 (neural crest) ( 1 ) , LAN-5 (neural crest) ( 1 ) , NBLW ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Treatments:
alectinib ( 1 ) , ceritinib ( 1 ) , crizotinib ( 1 ) , lorlatinib ( 1 ) , RG7388 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )

References 

1

Tucker ER, et al. (2023) Combination Therapies Targeting Alk-Aberrant Neuroblastoma in Preclinical Models. Clin Cancer Res
36602782   Curated Info

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