Ser312
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Home > Phosphorylation Site Page: > Ser312  -  CTNND1 (mouse)

Site Information
ARRtGtPsDPRRRLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450458

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 6 ) , [32P] bio-synthetic labeling ( 6 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 1 , 2 , 6 ) , phosphoamino acid analysis ( 6 ) , phosphopeptide mapping ( 6 )
Disease tissue studied:
colorectal cancer ( 1 , 2 ) , colorectal carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 6 ) , COLO-205 (intestinal) ( 1 , 2 , 6 ) , fibroblast-lung ( 4 , 5 ) , HCT116 (intestinal) ( 6 )

Downstream Regulation
Effects of modification on CTNND1:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell adhesion, inhibited ( 2 )

References 

1

Maiden SL, Petrova YI, Gumbiner BM (2016) Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. PLoS One 11, e0148574
26845024   Curated Info

2

Shashikanth N, et al. (2015) Allosteric Regulation of E-Cadherin Adhesion. J Biol Chem 290, 21749-61
26175155   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Guo A (2010) CST Curation Set: 9809; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

5

Guo A (2010) CST Curation Set: 9027; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

6

Xia X, Mariner DJ, Reynolds AB (2003) Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin. Biochemistry 42, 9195-204
12885254   Curated Info

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