Thr310
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Home > Phosphorylation Site Page: > Thr310  -  CTNND1 (mouse)

Site Information
GtARRtGtPsDPRRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450457

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 11 ) , [32P] bio-synthetic labeling ( 11 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 5 , 6 , 7 , 8 , 9 ) , mutation of modification site ( 1 , 2 , 3 , 10 , 11 ) , phospho-antibody ( 3 , 10 ) , phosphoamino acid analysis ( 11 ) , phosphopeptide mapping ( 11 ) , western blotting ( 3 , 10 )
Disease tissue studied:
breast cancer ( 3 ) , colorectal cancer ( 1 , 2 , 3 , 10 ) , colorectal carcinoma ( 1 , 2 , 3 , 10 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 10 , 11 ) , A431 (epithelial) ( 3 , 10 ) , COLO-205 (intestinal) ( 1 , 2 , 11 ) , COS (fibroblast) ( 10 ) , ES-J1 (stem) ( 8 ) , fibroblast-lung ( 7 , 9 ) , HCT116 (intestinal) ( 3 , 10 , 11 ) , liver ( 5 ) , liver [leptin (mouse), homozygous knockout] ( 5 ) , MDA-MB-231 (breast cell) ( 3 ) , MDCK (epithelial) ( 3 , 10 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 6 ) , SW48 (intestinal) ( 3 )

Upstream Regulation
Kinases, in vitro:
GSK3B (human) ( 11 )

Downstream Regulation
Effects of modification on CTNND1:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell adhesion, inhibited ( 1 , 2 )

References 

1

Maiden SL, Petrova YI, Gumbiner BM (2016) Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. PLoS One 11, e0148574
26845024   Curated Info

2

Shashikanth N, et al. (2015) Allosteric Regulation of E-Cadherin Adhesion. J Biol Chem 290, 21749-61
26175155   Curated Info

3

Kourtidis A, et al. (2015) Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer. PLoS One 10, e0129964
26067913   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

6

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

7

Guo A (2010) CST Curation Set: 9809; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

8

Zhou J (2010) CST Curation Set: 9670; Year: 2010; Biosample/Treatment: cell line, ES J1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

9

Guo A (2010) CST Curation Set: 9033; Year: 2010; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

10

Xia X, Brooks J, Campos-González R, Reynolds AB (2004) Serine and threonine phospho-specific antibodies to p120-catenin. Hybrid Hybridomics 23, 343-51
15684660   Curated Info

11

Xia X, Mariner DJ, Reynolds AB (2003) Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin. Biochemistry 42, 9195-204
12885254   Curated Info

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