Tyr221
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Home > Phosphorylation Site Page: > Tyr221  -  SOCS3 (mouse)

Site Information
IREFLDQyDAPL___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450447

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
BaF3 ('B lymphocyte, precursor') ( 1 ) , liver ( 1 ) , lymph node ( 1 ) , spleen ( 1 )

Upstream Regulation
Treatments:
ruxolitinib ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell cycle regulation ( 1 ) , cell growth, inhibited ( 1 )

References 

1

Funakoshi-Tago M, et al. (2019) Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant. Cytokine 123, 154753
31255914   Curated Info

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