Tyr767
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Home > Phosphorylation Site Page: > Tyr767  -  DDEF1 (human)

Site Information
RDKQRLSyGAFTNQI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450438

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , A375MM (melanocyte) ( 2 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
KDELR1 (human) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, induced ( 2 )

References 

1

Tsai YL, et al. (2018) Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling. Proc Natl Acad Sci U S A 115, E4245-E4254
29654145   Curated Info

2

Ruggiero C, et al. (2015) A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation. Oncotarget 6, 3375-93
25682866   Curated Info

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