Ser87
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Home > Phosphorylation Site Page: > Ser87  -  XIAP (human)

Site Information
VGRHRKVsPNCRFIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450336

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 2 , 4 , 5 ) , phospho-antibody ( 1 , 5 ) , western blotting ( 1 , 5 )
Disease tissue studied:
leukemia ( 4 ) , acute lymphocytic leukemia ( 4 ) , ovarian cancer ( 5 ) , pancreatic cancer ( 1 , 2 ) , pancreatic carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 5 ) , A2780 (ovarian) ( 5 ) , Aspc1 (pancreatic) ( 1 ) , BxPC-3 (pancreatic) ( 2 ) , CEM (T lymphocyte) ( 4 ) , COS (fibroblast) ( 5 ) , PANC-1 (pancreatic) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 4 , 5 ) , Akt2 (human) ( 5 )
Kinases, in vitro:
Akt1 (human) ( 5 ) , Akt2 (human) ( 5 )
Treatments:
BNTX ( 1 ) , insulin ( 5 ) , LY294002 ( 5 ) , TRAIL ( 1 )

Downstream Regulation
Effects of modification on XIAP:
protein stabilization ( 4 , 5 )
Effects of modification on biological processes:
apoptosis, altered ( 4 ) , apoptosis, inhibited ( 2 , 5 )

References 

1

Kim SY, et al. (2017) Downregulation of X-linked inhibitor of apoptosis protein by '7-Benzylidenenaltrexone maleate' sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Oncotarget 8, 61057-61071
28977846   Curated Info

2

Moon JH, et al. (2015) A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer. Oncotarget 6, 26895-908
26314849   Curated Info

3

Huang X, Wu Z, Mei Y, Wu M (2013) XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J 32, 2204-16
23749209   Curated Info

4

Bornhauser BC, et al. (2007) Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. Blood 110, 2084-91
17537996   Curated Info

5

Dan HC, et al. (2004) Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279, 5405-12
14645242   Curated Info