Ser273
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Home > Phosphorylation Site Page: > Ser273  -  NEK11 (human)

Site Information
SMLNKNPsLRPSAIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10433801

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 1 )
Kinases, in vitro:
Chk1 (human) ( 1 )
Treatments:
caffeine ( 1 ) , Go_6976 ( 1 ) , ionizing_radiation ( 1 )

Downstream Regulation
Effects of modification on NEK11:
enzymatic activity, induced ( 1 )

References 

1

Melixetian M, Klein DK, Sørensen CS, Helin K (2009) NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol 11, 1247-53
19734889   Curated Info

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