Tyr1349
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Home > Phosphorylation Site Page: > Tyr1349  -  INSR iso2 (human)

Site Information
SyEEHIPyTHMNGGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447684

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 2 ) , peptide sequencing ( 1 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 1 ) , Rat1 (fibroblast) ( 2 )

Upstream Regulation
Kinases, in vitro:
INSR (human) ( 1 )
Treatments:
insulin ( 1 )

Downstream Regulation
Effects of modification on INSR iso2:
activity, inhibited ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Tennagels N, et al. (2001) Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells. Biochem Biophys Res Commun 282, 387-93
11401470   Curated Info

2

Takata Y, Webster NJ, Olefsky JM (1991) Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem 266, 9135-9
2026614   Curated Info

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