Thr547
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Home > Phosphorylation Site Page: > Thr547  -  Abl (mouse)

Site Information
EQKDAPDtPELLHTK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450294

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 ) , phosphopeptide mapping ( 1 , 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , 3T3 (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK1 (mouse) ( 2 )
Treatments:
fibronectin ( 1 ) , nocodazole ( 1 ) , okadaic_acid ( 1 , 2 )

Downstream Regulation
Effects of modification on Abl:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Woodring PJ, Hunter T, Wang JY (2005) Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem 280, 10318-25
15632178   Curated Info

2

Kipreos ET, Wang JY (1990) Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science 248, 217-20
2183353   Curated Info

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