Ser341
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Home > Phosphorylation Site Page: > Ser341  -  E2A (human)

Site Information
KALASIYsPDHssNN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10359100

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
MLK2 (human) ( 3 )
Kinases, in vitro:
MLK2 (human) ( 3 )

Downstream Regulation
Effects of modification on E2A:
activity, inhibited ( 3 )
Effects of modification on biological processes:
transcription, inhibited ( 3 )

References 

1

Guo A (2011) CST Curation Set: 11892; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

2

Guo A (2011) CST Curation Set: 11893; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

3

Pedraza N, et al. (2009) Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J Biol Chem 284, 32980-8
19801649   Curated Info

4

Gu T (2009) CST Curation Set: 6994; Year: 2009; Biosample/Treatment: cell line, K562/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: PXpTPAntibodies Used to Purify Peptides prior to LCMS: Phospho-MAPK Substrates (PXTP) (46G11) Rabbit mAb Cat#: 4391, PTMScan(R) Phospho-MAPK Substrate Motif (PXpTP) Immunoaffinity Beads Cat#: 1983
Curated Info