Ser154
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Home > Phosphorylation Site Page: > Ser154  -  p90RSK (rat)

Site Information
GDLFTRLsKEVMFTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10355000

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on p90RSK:
enzymatic activity, induced ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:
14-3-3 beta (human) ( 2 )

References 

1

Gao X, Chaturvedi D, Patel TB (2010) p90 Ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. J Biol Chem 285, 6970-9
20048145   Curated Info

2

Cavet ME, Lehoux S, Berk BC (2003) 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. J Biol Chem 278, 18376-83
12618428   Curated Info