Ser104

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Home > Phosphorylation Site Page: > Ser104 - TPH2 (human)

Site Information
RKSRRRSsEVEIFVD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1033700

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , brain ( 1 )

Upstream Regulation
Kinases, in vitro:	PKACA (cow) ( 1 )

Downstream Regulation
Effects of modification on TPH2:	molecular association, regulation ( 1 )
Induce interaction with:	14-3-3 epsilon (human) ( 1 ) , 14-3-3 gamma (human) ( 1 )

References
1	Winge I, et al. (2008) Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochem J 410, 195-204 17973628 Curated Info

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