Tyr245
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Home > Phosphorylation Site Page: > Tyr245  -  Abl iso2 (human)

Site Information
KRNKPTVyGVSPNYD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450303

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , fibroblast-skin ( 4 )

Upstream Regulation
Treatments:
high_cell_density ( 2 ) , imatinib ( 3 ) , ionizing_radiation ( 2 ) , low_cell_density ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
scleroderma ( 4 )

References 

1

Dunn DM, et al. (2015) c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Rep 12, 1006-18
26235616   Curated Info

2

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
23852372   Curated Info

3

Kaidi A, Jackson SP (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-4
23708966   Curated Info

4

Noda S, et al. (2012) Constitutive activation of c-Abl/protein kinase C-δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma. Br J Dermatol 167, 1098-105
22591006   Curated Info