Tyr245
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Home > Phosphorylation Site Page: > Tyr245  -  Abl iso2 (human)

Site Information
KRNKPTVyGVSPNYD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450303

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 5 ) , phospho-antibody ( 1 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 3 , 4 , 5 , 6 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 , 4 ) , fibroblast-skin ( 6 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
BAP37 (human) ( 1 )
Treatments:
high_cell_density ( 4 ) , imatinib ( 1 , 5 ) , ionizing_radiation ( 4 ) , low_cell_density ( 4 ) , MPP+ ( 1 )

Downstream Regulation
Effects of modification on Abl iso2:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, inhibited ( 1 )
Induce interaction with:
BAP37 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Parkinson's disease ( 1 ) , scleroderma ( 6 )

References 

1

Zhang Y, et al. (2022) Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model. Oxid Med Cell Longev 2022, 9233749
36406767   Curated Info

2

¿¿berg M, Ed¿¿n D, Siegbahn A (2020) Activation of ¿¿1 integrins and caveolin-1 by TF/FVIIa promotes IGF-1R signaling and cell survival. Apoptosis
32458278   Curated Info

3

Dunn DM, et al. (2015) c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Rep 12, 1006-18
26235616   Curated Info

4

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
23852372   Curated Info

5

Kaidi A, Jackson SP (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-4
23708966   Curated Info

6

Noda S, et al. (2012) Constitutive activation of c-Abl/protein kinase C-δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma. Br J Dermatol 167, 1098-105
22591006   Curated Info

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