Tyr412
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Home > Phosphorylation Site Page: > Tyr412  -  Abl iso2 (human)

Site Information
RLMTGDtyTAHAGAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450298

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 , 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 3 ) , glioblastoma ( 3 ) , glioma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
EGFR (human) ( 3 ) , MIG-6 (human) ( 2 )
Putative in vivo kinases:
Abl (human) ( 2 , 4 )
Treatments:
EGF ( 2 ) , high_cell_density ( 1 ) , ionizing_radiation ( 1 ) , low_cell_density ( 1 ) , vanadate ( 4 )

Downstream Regulation
Effects of modification on Abl iso2:
enzymatic activity, induced ( 2 , 4 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , transcription, altered ( 4 )

References 

1

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
23852372   Curated Info

2

Hopkins S, et al. (2012) Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell 23, 547-59
22975324   Curated Info

3

Lu KV, et al. (2009) Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res 69, 6889-98
19690143   Curated Info

4

Dorey K, et al. (2001) Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase. Oncogene 20, 8075-84
11781820   Curated Info