Tyr412
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Home > Phosphorylation Site Page: > Tyr412  -  Abl iso2 (human)

Site Information
RLMTGDtyTAHAGAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450298

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 , 2 , 3 , 5 ) , western blotting ( 2 , 3 )
Disease tissue studied:
brain cancer ( 4 ) , glioblastoma ( 4 ) , glioma ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 5 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 5 ) , HEK293T (epithelial) ( 3 ) , ovary ( 1 ) , U87MG (glial) [EGFR (human), transfection] ( 4 ) , U87MG (glial) ( 4 )

Upstream Regulation
Regulatory protein:
EGFR (human) ( 4 ) , MIG-6 (human) ( 3 )
Putative in vivo kinases:
Abl (human) ( 3 , 5 )
Treatments:
EGF ( 3 ) , high_cell_density ( 2 ) , ionizing_radiation ( 2 ) , low_cell_density ( 2 ) , neoadjuvant chemotherapy ( 1 ) , vanadate ( 5 )

Downstream Regulation
Effects of modification on Abl iso2:
enzymatic activity, induced ( 3 , 5 )
Effects of modification on biological processes:
apoptosis, induced ( 3 ) , transcription, altered ( 5 )

References 

1

Jordan KR, et al. (2020) The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval. Clin Cancer Res
32928797   Curated Info

2

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
23852372   Curated Info

3

Hopkins S, et al. (2012) Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell 23, 547-59
22975324   Curated Info

4

Lu KV, et al. (2009) Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res 69, 6889-98
19690143   Curated Info

5

Dorey K, et al. (2001) Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase. Oncogene 20, 8075-84
11781820   Curated Info

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