Tyr488
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Home > Phosphorylation Site Page: > Tyr488  -  Abl iso2 (human)

Site Information
EGCPEKVyELMRACW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450295

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Regulatory protein:
Fyn (human) ( 2 ) , MIG-6 (human) ( 2 ) , Yes (human) ( 2 )
Putative in vivo kinases:
Src (human) ( 2 )
Kinases, in vitro:
Src (human) ( 2 )
Treatments:
EGF ( 2 ) , PP2 ( 2 ) , SU6656 ( 2 )

Downstream Regulation
Effects of modification on Abl iso2:
molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 )
Inhibit interaction with:
MIG-6 (human) ( 2 )

References 

1

Zhou Y, et al. (2020) Abl-mediated PI3K activation regulates macrophage podosome formation. J Cell Sci
32393599   Curated Info

2

Hopkins S, et al. (2012) Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Dev Cell 23, 547-59
22975324   Curated Info

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