Ser558
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Home > Phosphorylation Site Page: > Ser558  -  NRF2 (human)

Site Information
HLLkkQLstLyLEVF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10292703

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 ) , Th17 ( 1 )

Upstream Regulation
Putative in vivo kinases:
MAPKAPK5 (human) ( 1 )

Downstream Regulation
Effects of modification on NRF2:
intracellular localization ( 1 , 2 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell differentiation, inhibited ( 1 ) , transcription, induced ( 2 )

References 

1

Zhao Z, et al. (2023) The PRAK-NRF2 axis promotes the differentiation of Th17 cells by mediating the redox homeostasis and glycolysis. Proc Natl Acad Sci U S A 120, e2212613120
37126714   Curated Info

2

Sun Z, Huang Z, Zhang DD (2009) Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 4, e6588
19668370   Curated Info