Ser577
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Home > Phosphorylation Site Page: > Ser577  -  NRF2 (human)

Site Information
DEDGkPysPSEYSLQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10292702

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 ( 1 ) , JNK1 (human) ( 1 )
Treatments:
SP600125 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on NRF2:
intracellular localization ( 3 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 3 )
Induce interaction with:
PIN1 (human) ( 1 )

References 

1

Saeidi S, et al. (2022) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 directly binds and stabilizes Nrf2 in breast cancer. FASEB J 36, e22068
34918396   Curated Info

2

Matzinger M, et al. (2020) AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes. Redox Biol 29, 101393
31805502   Curated Info

3

Sun Z, Huang Z, Zhang DD (2009) Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 4, e6588
19668370   Curated Info