Tyr638
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Home > Phosphorylation Site Page: > Tyr638  -  PTPRE iso2 (mouse)

Site Information
FIDIFSDyANFK___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450705

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CHO beta3 ( 1 ) , osteoclast ( 1 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Regulatory protein:
Src (human) ( 1 )
Treatments:
vitronectin ( 1 )

Downstream Regulation
Effects of modification on PTPRE iso2:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 1 )
Induce interaction with:
Pyk2 (human) ( 1 ) , Src (human) ( 1 )

References 

1

Granot-Attas S, Luxenburg C, Finkelshtein E, Elson A (2009) Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Mol Biol Cell 20, 4324-34
19692574   Curated Info