Ser244

Site Information
SSSSSSAsSYTGRPI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1028300

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , AGS-B (gastric) ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Downstream Regulation
Effects of modification on PRKD2:	intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:	signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:	14-3-3 eta (human) ( 1 ) , 14-3-3 eta (mouse) ( 1 ) , Exportin-1 (human) ( 1 )

References
1	von Blume J, et al. (2007) Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J 26, 4619-33 17962809 Curated Info
2	Possemato A (2007) CST Curation Set: 2927; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS:p[ST] Curated Info