Ser289
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Home > Phosphorylation Site Page: > Ser289  -  FAF1 (human)

Site Information
ITDVHMVsDsDGDDF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450286

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 3 ) , western blotting ( 1 )
Disease tissue studied:
luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , COS (fibroblast) ( 4 ) , HeLa (cervical) ( 3 ) , MEF (fibroblast) ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 3 )
Kinases, in vitro:
AurA (human) ( 3 ) , CK2A1 (human) ( 4 )
Treatments:
taxol ( 3 ) , VX-680 ( 3 )

Downstream Regulation
Effects of modification on FAF1:
intracellular localization ( 1 , 4 )
Effects of modification on biological processes:
cell cycle regulation ( 3 )

References 

1

Yu C, Kim BS, Kim E (2016) FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell Death Differ 23, 1873-1885
27662363   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Jang MS, et al. (2008) Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. J Biol Chem 283, 32344-51
18790738   Curated Info

4

Olsen BB, et al. (2003) Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus. FEBS Lett 546, 218-22
12832043   Curated Info