Lys6

Site Information
__MAtLEkLMkAFEs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 10206806

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 3 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 3 ) , ST14A ( 3 )

Downstream Regulation
Effects of modification on Huntingtin:	protein conformation ( 2 ) , protein stabilization ( 2 )

References
1	Chiki A, et al. (2021) Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation. Front Mol Biosci 8, 686086 34381813 Curated Info
2	Chiki A, et al. (2017) Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6. Angew Chem Int Ed Engl 56, 5202-5207 28334491 Curated Info
3	Aiken CT, et al. (2009) Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem 284, 29427-36 19710014 Curated Info