Ser13
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Home > Phosphorylation Site Page: > Ser13  -  Huntingtin (mouse)

Site Information
KLMkAFEsLKsFQQQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10206805

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 , 2 ) , immunoprecipitation ( 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
Huntington's disease ( 1 , 3 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 2 , 3 ) , 'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 4 ) , 'neuron, striatal' ( 1 ) , astrocyte-'brain, striatum' ( 2 ) , brain ( 1 ) , HEK293T (epithelial) ( 1 ) , liver ( 2 ) , STHdh ('neuron, striatal') ( 1 )

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 2 )
Treatments:
4b ( 4 ) , fingolimod ( 3 ) , ganglioside_GM1 ( 1 ) , tamoxifen ( 2 )

Downstream Regulation
Effects of modification on Huntingtin:
protein degradation ( 2 )
Effects of modification on biological processes:
autophagy, induced ( 2 ) , transcription, induced ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
Huntington's disease ( 2 )

References 

1

Cariulo C, et al. (2019) Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochem Biophys Res Commun
31677786   Curated Info

2

Ochaba J, et al. (2019) IKK╬▓ slows Huntington's disease progression in R6/1 mice. Proc Natl Acad Sci U S A 116, 10952-10961
31088970   Curated Info

3

Di Pardo A, et al. (2014) FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. Hum Mol Genet 23, 2251-65
24301680   Curated Info

4

Jia H, Kast RJ, Steffan JS, Thomas EA (2012) Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet 21, 5280-93
22965876   Curated Info