Tyr1100
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Home > Phosphorylation Site Page: > Tyr1100  -  TIE2 (mouse)

Site Information
MLEERKTyVNTTLYE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450256

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
TIE2 (mouse) ( 2 , 3 )
Kinases, in vitro:
TIE2 (mouse) ( 2 )
Treatments:
M-CSF ( 2 )

Downstream Regulation
Effects of modification on TIE2:
molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:
transcription, altered ( 2 )
Induce interaction with:
GRB14 (mouse) ( 3 ) , GRB2 (mouse) ( 3 ) , GRB7 (mouse) ( 3 ) , PIK3R1 (mouse) ( 2 , 3 ) , SHP-2 (mouse) ( 3 )

References 

1

Jones N, et al. (2003) A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Mol Cell Biol 23, 2658-68
12665569   Curated Info

2

Kontos CD, Cha EH, York JD, Peters KG (2002) The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol 22, 1704-13
11865050   Curated Info

3

Jones N, et al. (1999) Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem 274, 30896-905
10521483   Curated Info