Ser486
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Home > Phosphorylation Site Page: > Ser486  -  ERK5 (mouse)

Site Information
LKAALLKsLRSRLRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450251

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 3 ) , HUVEC (endothelial) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCZ (human) ( 2 )

Downstream Regulation
Effects of modification on ERK5:
enzymatic activity, inhibited ( 3 ) , molecular association, regulation ( 3 )
Induce interaction with:
14-3-3 beta (mouse) ( 3 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Nigro P, et al. (2010) PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood 116, 1971-9
20538799   Curated Info

3

Zheng Q, et al. (2004) 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function. J Biol Chem 279, 8787-91
14679215   Curated Info