Ser432
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Home > Phosphorylation Site Page: > Ser432  -  GABRB3 (mouse)

Site Information
KTHLRRRssQLKIKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450245

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 , 8 ) , mutation of modification site ( 2 , 4 , 5 , 7 ) , phospho-antibody ( 1 , 2 , 4 , 6 ) , phosphoamino acid analysis ( 8 ) , phosphopeptide mapping ( 8 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 5 ) , Status epilepticus ( 4 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 2 ) , 'neuron, cortical'-brain ( 6 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 4 ) , 293 (epithelial) ( 7 ) , A293 ('renal, embryonic') ( 8 ) , neuron-'brain, cerebral cortex' ( 8 ) , NG108-15 (neuron) ( 5 ) , spinal cord ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (mouse) ( 4 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 4 )
Treatments:
acetic acid ( 1 ) , colforsin ( 6 , 8 ) , GF109203X ( 4 ) , HBO2 ( 1 ) , okadaic_acid ( 4 ) , phorbol_ester ( 2 , 4 ) , pilocarpine ( 4 ) , scopolamine ( 4 )

Downstream Regulation
Effects of modification on GABRB3:
molecular association, regulation ( 4 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )
Inhibit interaction with:
AP-2 alpha (mouse) ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
Status epilepticus ( 4 )

References 

1

Brewer AL, et al. (2018) Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen. Brain Res
30077648   Curated Info

2

Vien TN, et al. (2015) Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci U S A 112, 14805-10
26627235   Curated Info

3

Abramian AM, et al. (2010) Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem 285, 41795-805
20940303   Curated Info

4

Terunuma M, et al. (2008) Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci 28, 376-84
18184780   Curated Info

5

Houston CM, et al. (2007) Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors. J Biol Chem 282, 17855-65
17442679   Curated Info

6

Yanagihori S, et al. (2006) Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor. Adv Enzyme Regul 46, 203-22
16854455   Curated Info

7

Hinkle DJ, Macdonald RL (2003) Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents. J Neurosci 23, 11698-710
14684872   Curated Info

8

Brandon NJ, et al. (2000) GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem 275, 38856-62
10978327   Curated Info