Ser432
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Home > Phosphorylation Site Page: > Ser432  -  GABRB3 (human)

Site Information
KTHLRRRssQLKIKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450245

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Treatments:
APV ( 1 ) , ciclosporin ( 1 ) , deoxygenation ( 1 ) , ischemia ( 1 ) , okadaic_acid ( 1 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on GABRB3:
receptor internalization, inhibited ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )

References 

1

Mele M, et al. (2014) GABA(A) receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia. Neurobiol Dis 65, 220-32
24513087   Curated Info

2

Abramian AM, et al. (2010) Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem 285, 41795-805
20940303   Curated Info

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