Ser434
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Home > Phosphorylation Site Page: > Ser434  -  GABRB1 (mouse)

Site Information
GRIRRRAsQLKVKIP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450244

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , 293 (epithelial) ( 2 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (rat) ( 3 ) , PKACA (cow) ( 4 ) , PKG1 (mouse) ( 3 )

Downstream Regulation
Effects of modification on GABRB1:
receptor desensitization, altered ( 2 )

References 

1

Kang SU, Heo S, Lubec G (2011) Mass spectrometric analysis of GABA(A) receptor subtypes and phosphorylations from mouse hippocampus. Proteomics 11, 2171-81
21538884   Curated Info

2

Hinkle DJ, Macdonald RL (2003) Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents. J Neurosci 23, 11698-710
14684872   Curated Info

3

McDonald BJ, Moss SJ (1994) Differential phosphorylation of intracellular domains of gamma-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J Biol Chem 269, 18111-7
8027073   Curated Info

4

Moss SJ, Doherty CA, Huganir RL (1992) Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor. J Biol Chem 267, 14470-6
1321150   Curated Info