Ser603
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser603  -  SYN1 (rat)

Site Information
AGPIRQAsQAGPGPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450236

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , peptide sequencing ( 11 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 6 , 7 , 8 , 9 , 10 ) , phosphopeptide mapping ( 11 ) , western blotting ( 1 , 2 , 3 , 4 , 6 , 7 , 8 , 9 , 10 )
Disease tissue studied:
adrenal cancer ( 10 ) , pheochromocytoma ( 10 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 , 4 , 7 ) , 'brain, hippocampus' ( 2 , 3 , 4 , 6 ) , 'brain, hypothalamus' ( 8 ) , PC-12 (chromaffin) ( 10 ) , SF9 ( 9 )

Upstream Regulation
Putative in vivo kinases:
PAK1 (rat) ( 10 )
Kinases, in vitro:
CAMK2A (rat) ( 11 )
Treatments:
bisphenol_A ( 5 ) , bradykinin ( 10 ) , depolarization ( 10 ) , diabetes ( 3 ) , estradiol ( 8 ) , glutamic acid ( 10 ) , KN-62 ( 10 ) , microwave_exposure ( 2 ) , monocular_deprivation ( 7 ) , NGF ( 10 ) , nicotine ( 10 ) , okadaic_acid ( 9 ) , PAF ( 6 ) , ST101 ( 4 ) , U0126 ( 5 )

Downstream Regulation
Effects of modification on SYN1:
intracellular localization ( 8 )

Disease / Diagnostics Relevance
Relevant diseases:
type 2 diabetes ( 3 )

References 

1

Sun WL, et al. (2014) Relapse to cocaine-seeking after abstinence is regulated by cAMP-dependent protein kinase A in the prefrontal cortex. Addict Biol 19, 77-86
23461423   Curated Info

2

Qiao S, et al. (2014) Reduction of Phosphorylated Synapsin I (Ser-553) Leads to Spatial Memory Impairment by Attenuating GABA Release after Microwave Exposure in Wistar Rats. PLoS One 9, e95503
24743689   Curated Info

3

Liao MH, et al. (2013) The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus. CNS Neurosci Ther 19, 329-36
23490331   Curated Info

4

Moriguchi S, et al. (2012) The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101: enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices. J Neurochem 121, 44-53
22251222   Curated Info

5

Iwakura T, et al. (2010) In vitro effects of bisphenol A on developing hypothalamic neurons. Toxicology 272, 52-8
20399245   Curated Info

6

Moriguchi S, Shioda N, Yamamoto Y, Fukunaga K (2010) Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. Neuroscience 166, 1158-66
20074623   Curated Info

7

Scott LL, Kogan D, Shamma AA, Quinlan EM (2010) Differential regulation of synapsin phosphorylation by monocular deprivation in juveniles and adults. Neuroscience 166, 539-50
20035839   Curated Info

8

Ohtani-Kaneko R, et al. (2010) Effects of estrogen on synapsin I distribution in developing hypothalamic neurons. Neurosci Res 66, 180-8
19896987   Curated Info

9

Tu Y, Nayak SK, Woodson J, Ross EM (2003) Phosphorylation-regulated inhibition of the Gz GTPase-activating protein activity of RGS proteins by synapsin I. J Biol Chem 278, 52273-81
14557263   Curated Info

10

Sakurada K, et al. (2002) Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. J Biol Chem 277, 45473-9
12237306   Curated Info

11

Czernik AJ, Pang DT, Greengard P (1987) Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci U S A 84, 7518-22
3118371   Curated Info