Ser605
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Home > Phosphorylation Site Page: > Ser605  -  SYN1 (mouse)

Site Information
AGPtRQAsQAGPGPr   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450236

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 6 , 7 , 8 , 9 , 10 , 12 , 14 ) , phospho-antibody ( 1 , 2 , 11 , 13 , 15 ) , western blotting ( 1 , 2 , 11 , 13 , 15 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 12 ) , 'brain, embryonic' ( 14 ) , 'brain, hippocampus' ( 13 ) , 'brain, visual cortex' ( 1 ) , 'neuron, hippocampal' ( 11 ) , brain ( 6 , 7 , 8 , 9 , 10 ) , GT1-7 (neuron) ( 15 ) , neuron-'brain, cerebral cortex' ( 2 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 11 ) , PKCG (mouse) ( 1 )
Kinases, in vitro:
CAMK2A (rat) ( 15 )
Treatments:
9d ( 13 ) , deoxygenation ( 2 ) , development ( 1 ) , ginsenoside-Rg1 ( 11 ) , GnRH ( 15 ) , ischemia/reperfusion ( 2 ) , iturelix ( 15 ) , KCl ( 15 ) , KN-93 ( 11 , 15 ) , nifedipine ( 15 )

Downstream Regulation
Effects of modification on biological processes:
neural plasticity ( 1 ) , signaling pathway regulation ( 1 )

References 

1

Fu T, et al. (2019) Modulation of cPKCγ on Synapsin-Ia/b-Specific Phosphorylation Sites in the Developing Visual Cortex of Mice. Invest Ophthalmol Vis Sci 60, 2676-2684
31242289   Curated Info

2

Zhang N, et al. (2018) cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice. Brain Res Bull 142, 156-162
30016727   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Kang MJ, et al. (2013) Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes. Exp Mol Med 45, e29
23807304   Curated Info

5

Qin Z, et al. (2013) Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One 8, e80758
24224061   Curated Info

6

Possemato A (2010) CST Curation Set: 9876; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

7

Possemato A (2010) CST Curation Set: 9879; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]XP Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) 14-3-3 Binding Motif (4E2) Mouse mAb Cat#: 9606
Curated Info

8

Possemato A (2010) CST Curation Set: 9878; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]XP Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) 14-3-3 Binding Motif (4E2) Mouse mAb Cat#: 9606
Curated Info

9

Possemato A (2010) CST Curation Set: 9877; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

10

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

11

Liu ZJ, et al. (2010) Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway. Brain Res 1333, 1-8
20381470   Curated Info

12

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

13

Tallent MK, et al. (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284, 174-81
19004831   Curated Info

14

Possemato A (2008) CST Curation Set: 3818; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

15

Yamanaka A, et al. (2007) Involvement of CaM kinase II in gonadotropin-releasing hormone-induced activation of MAP kinase in cultured hypothalamic neurons. Arch Biochem Biophys 466, 234-41
17706588   Curated Info