Ser63
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Home > Phosphorylation Site Page: > Ser63  -  calsenilin (human)

Site Information
APQGSDSsDSELELS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450214

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
H4 (glial) ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 1 )
Treatments:
calyculin_A ( 1 ) , ciclosporin ( 1 ) , colforsin ( 1 ) , FK506 ( 1 ) , okadaic_acid ( 1 ) , phorbol_ester ( 1 ) , staurosporine ( 1 ) , thapsigargin ( 1 )

Downstream Regulation
Effects of modification on calsenilin:
protein processing ( 1 )

References 

1

Choi EK, et al. (2003) Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3. Mol Cell Neurosci 23, 495-506
12837631   Curated Info