Multiple Sequence Alignment:
MDH1 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350  )
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MDH1 human ------------------MSEPIRVLVTGAAGQIAYSLLySIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIAtDkEDVAFKDLDVAILVGsMPRREGMERKDLLkANVkIFksQGAALDkyAKKSVkVIVVGNPANTNCLTASkSAPSIPkENFSCLTRLDHNRAkAQIALKLGVtANDVkNVIIWGNHsstQyPDVNHAKVKLQGkEVGVyEALkDDsWLkGEFVTTVQQrGAAVIKARKLssAMsAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKtWkFVEGLPINDFsREkMDLTAkELtEEkEsAFEFLssA
MDH1 iso2 human -----------------------------------------------------------------------------------------------------------MPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
MDH1 iso3 human MRRCsYFPKDVTVFDKDDKSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
MDH1 mouse ------------------MSEPIRVLVTGAAGQIAYSLLysIGNGsVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLQDVIATDKEEIAFKDLDVAVLVGSMPRREGMERKDLLkANVkIFksQGTALEkyAKKSVkVIVVGNPANTNCLTASkSAPSIPkENFSCLTRLDHNRAkSQIALkLGVTADDVkNVIIWGnHssTQYPDVNHAkVKLQGkEVGVyEALkDDsWLkGEFITTVQQrGAAVIKARKLssAMsAAKAIADHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWkFVEGLPINDFSREkMDLTAkELTEEkETAFEFLssA
MDH1 rat ------------------MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLQDVIATDKEEVAFKDLDVAVLVGSMPRREGMERKDLLkANVkIFkSQGAALEkyAKKSVKVIVVGNPANTNCLTASkSAPSIPKENFSCLTRLDHNRAkSQIALKLGVTADDVkNVIIWGNHsSTQYPDVNHAKVKLQGkEVGVYEALkDDsWLkGEFITTVQQRGAAVIkARKLsSAMSAAKAISDHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWkFVEGLPINDFSREkMDLTAkELTEEKETAFEFLssA
MDH1 pig ------------------MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQrGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIVEGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
                    :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::..::::::::.::::****:****************:**:**:***********************************************:*********::***************************:********:**********:**************************:**:****************:*******************:**:****:*********************:****:********
Consensus ------------------MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.