Multiple Sequence Alignment:
Mad1	Download MSA

	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 )
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Mad1 human	MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNkDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPEs sRHt tLsLLTkAKLHIKKLEDCDRkAVHQIDQLQREQRHLKRQLEkLGIERIRMDsIGSTVSSERSDSDREEIDV--------DVESTDYLTGDLDWSSSSVSDSDErGsMQsLGsDEGySSTSIKRIKLQDSHKACLGL
Mad1 mouse	MATAVGMNIQLLLEAADYLERREREAEHGYASMLPYS-KDRDAFKRRNKPKKNSTSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPEs sRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRRLEKLGAERTRMDSVGSVVSSERSDSDREELDVDVDVDVDVDVEGTDYLNGDLGWSS-SVSDSDERGSMQSLGSDEGYSSATVKRAKLQDGHKAGLGL
	::**:*********************:.*:*:::*************************************************************************:*::**::**********:........*:::.******************::::**::**
Consensus	MAAAVRMNIQLLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKPKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRRLEKLGAERIRMDSIGSTVSSERSDSDREEIDVDVDVDVDVDVEGTDYLNGDLDWSSSSVSDSDERGSMQSLGSDEGYSSASIKRAKLQDGHKACLGL

Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.

Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.