(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810       820       830       840       850       860       870       880       890       900       910       920       930       940       950       960       970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080      1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200      1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320      1330      1340      1350      1360      1370      1380      1390      1400      1410      1420      1430      1440      1450      1460      1470      1480      1490      1500      1510      1520      1530      1540      1550      1560      1570      1580      1590      1600      1610      1620      1630      1640      1650      1660      1670      1680      1690      1700      1710      1720      1730      1740      1750      1760      1770      1780      1790      1800      1810      1820      1830      1840      1850      1860      1870      1880      1890      1900      1910      1920      1930      1940      1950      1960      1970      1980      1990      2000      2010      2020      2030      2040      2050      2060      2070      2080      2090      2100      2110      2120      2130      2140      2150      2160      2170      2180      2190      2200      2210      2220      2230      2240      2250      2260      2270      2280      2290      2300      2310      2320      2330      2340      2350      2360      2370      2380      2390      2400      2410      2420      2430      2440      2450      2460      2470      2480      2490      2500      2510      2520      2530      2540      2550      2560      2570      2580      2590      2600      2610      2620      2630      2640      2650      2660      2670 )
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PDE4DIP human	-----------------------------------------------------------------------------------------------------------------------------------------MSNGYRTLSQHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEASREDIyKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLkRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER--------------------QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQsLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNsHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQyRDNsDKTLEANEMLLEkLRQRIHDKAVALERAIDEkFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEAtMQsMEsLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLM-SQAPISNQQAEVTPTG-RLGKQTDQGsMQIPSRDDSTsLTAKEDVSIPRstLGDLDtVAGLEKELSNAKEELELMAKKERESQMELsALQsMMAVQEEELQVQAADMESLTRNIQIkEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEIsGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRsLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPsPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHI-RNTMLSLCLENAELKEQMGEAMsDGWEIEEDKEkGEVMVETVVTKEGLSEsSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGsPGKHQHQEEGN-VTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKyRVMLtGEsLVKQDsKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGsTLAsssERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARE--LSYLRQKIREGRGICYLITRHA--KDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAEsNsNPISLPtPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESAsTVPPASTATLLsNDLEADSSYYLNsAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVyQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGrGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNsKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANG-LGLDtsPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLE-----------VKSLRALPCTP-----AL
PDE4DIP iso2 human	MK-----EICR------ICA-----------------------RELCGNQRR-----------------------WI---------------FHTASKLN-----------------------------------------LQVLLSHVLGKDVPRDGKAEFACSKCAFMLD-RIYRFDTVIARIEALSIERLQKLLLEkDRLKFCIASMYRKNNDDSGAEIKAGNGTVDMSVLPDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADsDyEAICKVPRKVARsIsCGPssRWSTSICTEEPALsEVGPPDLASTKVPPDGESMEEETPGSSVESLDASVQAsPPQQKDEETERSAKELGKCDCCsDDQAPQHGCNHKLELALsMIKGLDYKP-------------IQsPRGSRLPIPVK-----SSLPGAKPGPSMTDGVSSGFLNR-----SLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLM-SQAPISNQQAEVTPTG-CLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
PDE4DIP iso4 human	-----------------------------------------------------------------------------------------------------------------------------------------MSNGYRTLSQHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEASREDIYKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER--------------------QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLM-SQAPISNQQAEVTPTG-RLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHI-RNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGN-VTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARE--LSYLRQKIREGRGICYLITRHA--KDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANG-LGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEEPCKKRSHQKSLKQQERWACPPFVQLPIC
PDE4DIP iso8 human	MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRsGDAtRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEASREDIyKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEER--------------------QQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
PDE4DIP iso13 human	MK-----EICR------ICA-----------------------RELCGNQRR-----------------------WI---------------FHTASKLN-----------------------------------------LQVLLSHVLGKDVPRDGKAEFACSKCAFMLD-RIYRFDTVIARIEALSIERLQKLLLEKDRLKFCIASMYRKNNDDSGAEIKAGNGTVDMSVLPDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDYEAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLELALSMIKGLDYKP-------------IQSPRGSRLPIPVK-----SSLPGAKPGPSMTDGVSSGFLNR-----SLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLM-SQAPISNQQAEVTPTG-RLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGG---------------ELESVRIHHKHAY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
PDE4DIP mouse	-----------------------------------------------------------------------------------------------------------------------------------------MSNGYRTLSQHL--NDLKKEN----------FSLKLRIYFLEERMQQKyEVSREDVYKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDRKQHLDKTWADAEDLNSQNEAELRRQVEER--------------------QQETEHVYELLGNKIQLLQEEPRLAKNEATEMETLVEAEKRCNLELSERWTNAAKNREDAAGDQEKPDQYSEALAQRDRRIEELRQSLAAQEGLVEQLSQEKRQLLHLLEEPASMEVQPVPKGLPTQQKPDLHETPTTQPPVSESHLAELQDKIQQTEATNKILQEKLNDLSCELKSAQESSQKQDTTIQSLKEMLKSRESETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQSALFCSQLEIQRLQRLVRQKERQLADGKRCVQLVEAAAQEREHQKEAAWKHNQELRKALQHLQGELHSKSQQLHVLEAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDNADKTLDTNEVFLEkLRQRIQDRAVALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCVLSANEATMQSMESLLRARGLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEVAEELCQRLQRKERMLQDLLSDRNKQAVEHEMEIQGLLQSMGTREQERQAAAEKMVQAFMERNSELQALRQYLGGKELMTSSQTFISNQPAGVTSIGPHHGEQTDQGSMQMPSRDDSTSLTAREEASIPRSTLGDSDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAMQEEELQVQAADLESLTRNVQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREkVASVEPQGQEVSGNkRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPENSERDGTLQVELEGAQVLRTRLEEVLGRSLERLSRLESLAAIGGG------------------------------------ELESVQAQ--------------------EMLHLRAEIHQHLEEKRKAEVELKELKAQIEEAGFSSVSHISRNTMLSLCLENAELKEQMGEAMSDGWEVEEDKEKGEVMLETVVAKGCLNENSLQAEFRKVQGKLKSAYNIINLLKEQLLLRssEGNSKEMPELLVRLAREVDRMNTGLP-SLGKHQHQEQENTTTARPGSRPQSLPLGAALSVDGYQLENKSQAQDSGHQPEFSLPGSTkHLRSQLAQCRQRYQDLQEKLLISEATVFAQANQLEkYRAVFS-ESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNNLRPVVLMEGLCSEQGYLDPVLVSPPAKKPLENKPGKQEEFRAHGTPDDSSLLRKDIRDLKAQLQNANkVIQNLRSRVRSLSATSDYSSSLERPRKLRAVATLEGASPHSVtDEDEGWLSDGtGAFYPPGLQAKkDLESLIQRVSQLEAQLPKTGLEGKLAEELRCASWPGKYDSLIQDQARE--LSYLRQKIREGRGICYLLTQHA--KDTVkSFEDLLRSNDIDYYLGQSFREQLAQGGQLTERLTSKLSTKDHKSEKEEAGLEPLALRLSRELQEKEKVIEVLQAkLDTRSLSPPSSHAVSDSHRSASTTSFLSDDIEACSDMDVASEYTHYDEKKPSPSH-----------------SAASASQGLKGESSSsPISLPTPQNPPKEASQAHPGFHFHSIPKPASLSQTPMHSALPSFVPFSPSGPPLLGCCETPMVSLAEAQQELQMLQKQLGESVSIAPPASTSTLLSNQTEASSPHYINPAQPHTPTRSTIELGRILEPGYLGSSGQWDMMRPQKGSVSGELSSGSSMYQLNSKPTGADLLEEHLGEIRNLRQRLEESICVNDRLREQLQHRLSSTARENGSTSHFYSQGLESMPQLYNENRALREENQSLQTRLSHASRGHSQEVDHLREALLSSRSQLQELEKELEQQKAERQQ-----------------------------------------------LSLQSELQIYESLCENPKKALKAFSLDSCHQVP--GELSCLVAEIRALRGQLEQSIEVNNRLRLQLEQQMDRGAGKASLGPIAVGQSFPDKAEPANLH---QGSAASPPVRDVGLNSPAMVLPNSSCSAPGSDHAIVTRTNNELSSDDSAAMKNPPKLEVDATDGPFANKHGRHVIGHVDDYDALQQQIGEGKLLIQKILSLMRSARSIPGQEAQDTEAPGNIsAHELRSSAKALNHALEESTSLLNMFWRAALPNTHGPVLVGKEGQLMEkELLDLRAQVSQQEQILQNTAARLKRANQRKKsMEQFIVSHLTRTHDVLKKARTNLE-----------MKSFRALTCTP-----AL
PDE4DIP iso2 mouse	MK-----EICR------ICA-----------------------RELCGNQRR-----------------------WI---------------FHTASKLN-----------------------------------------LQVLLSHVLGKDVSRDGKAEFACSKCAFMLD-RIYRFDTVIARIEALSLERLQKLLLEKDRLKFCIASMYRKNNDDSGEENKAGsGtVDIsGLPDMRYAALLQEDFAYSGFECWVENEDQINDSHSCHASEGPGNRPRRCRGCAALRVADsDyEAICKVPRKVARSIsYAPSSRWSTSICTEEPALsEVGPPDLASTKVPPDGESMEEGTPGSSVESLDASVQASPPQQKDEETERSAKELVKCDYCsDEQAPQHLCNHkLELALSMIkGLDYKP-------------IQsPRGSKLPIPVK-----SILPGAKPGHILTNGVSSSFLNR-----PLKPLYRTPVSYPWEISDGQELWDDLCDEYLPIGFQPVPKGLPTQQKPDLHETPTTQPPVSESHLAELQDKIQQTEATNKILQEKLNDLSCELKSAQESSQKQDTTIQSLKEMLKSRESETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQSALFCSQLEIQRLQRLVRQKERQLADGKRCVQLVEAAAQEREHQKEAAWKHNQELRKALQHLQGELHSKSQQLHVLEAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDNADKTLDTNEVFLEKLRQRIQDRAVALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCVLSANEATMQSMESLLRARGLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEVAEELCQRLQRKERMLQDLLSDRNKQAVEHEMEIQGLLQSMGTREQERQAAAEKMVQAFMERNSELQALRQYLGGKELMTSSQTFISNQPAGVTSIGPHHGEQTDQGSMQMPSRDDSTSLTAREEASIPRSTLGDSDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAMQEEELQVQAADLESLTRNVQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVEPQGQEVSGNKRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPENSERDGTLQVELEGAQVLRTRLEEVLGRSLERLSRLESLAAIGGG---------------ELESVQARHKHAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
PDE4DIP iso3 mouse	MKRTDSGSIC----------------HHAPPPCWAHHAPRQSPRQPSSRERRPPERAGSWAVAAEEEEAASAA-PWMRHYFGEDDGEMVPRTSSAAAFLSDTKDRGPPVQSQTWRSAERVPFGQAHSLRAFEKPPLVQTQALRDFEKHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEVSREDVYKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDRKQHLDKTWADAEDLNSQNEAELRRQVEER--------------------QQETEHVYELLGNKIQLLQEEPRLAKNEATEMETLVEAEKRCNLELSERWTNAAKNREDAAGDQEKPDQYSEALAQRDRRIEELRQSLAAQEGLVEQLSQEKRQLLHLLEEPASMEVQPVPKGLPTQQKPDLHETPTTQPPVSESHLAELQDKIQQTEATNKILQEKLNDLSCELKSAQESSQKQDTTIQSLKEMLKSRESETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQSALFCSQLEIQRLQRLVRQKERQLADGKRCVQLVEAAAQEREHQKEAAWKHNQELRKALQHLQGELHSKSQQLHVLEAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDNADKTLDTNEVFLEKLRQRIQDRAVALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCVLSANEATMQSMESLLRARGLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEVAEELCQRLQRKERMLQDLLSDRNKQAVEHEMEIQGLLQSMGTREQERQAAAEKMVQAFMERNSELQALRQYLGGKELMTSSQTFISNQPAGVTSIGPHHGEQTDQGSMQMPSRDDSTSLTAREEASIPRSTLGDSDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAMQEEELQVQAADLESLTRNVQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVEPQGQEVSGNKRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPENSERDGTLQVELEGAQVLRTRLEEVLGRSLERLSRLESLAAIGGATAGNETEDTSTEFTDSIEEEAAHTSHQQLIKVALEKSLATMETQNICLQPPsPVGEDSNRCLQEEMLHLRAEIHQHLEEKRKAEVELKELKAQIEEAGFSSVSHI-RNTMLSLCLENAELKEQMGEAMSDGWEVEEDKEKGEVMLETVVAKGCLNENSLQAEFRKVQGKLKSAYNIINLLKEQLLLRSSEGNSKEMPELLVRLAREVDRMNTGLP-SLGKHQHQEQENTTTARPGSRPQSLPLGAALSVDGYQLENKSQAQDSGHQPEFSLPGSTkHLRSQLAQCRQRYQDLQEKLLISEATVFAQANQLEkYRAVFS-ESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNNLRPVVLMEGLCSEQGYLDPVLVSPPAKKPLENKPGKQEEFRAHGTPDDSSLLRKDIRDLKAQLQNANkVIQNLRSRVRSLSATSDYSSSLERPRKLRAVATLEGASPHSVTDEDEGWLSDGTGAFYPPGLQAKkDLESLIQRVSQLEAQLPKTGLEGKLAEELRCASWPGKYDSLIQDQARE--LSYLRQKIREGRGICYLLTQHA--KDTVkSFEDLLRSNDIDYYLGQSFREQLAQGGQLTERLTSKLSTKDHKSEKEEAGLEPLALRLSRELQEKEKVIEVLQAkLDTRSLSPPSSHAVSDSHRSASTTSFLSDDIEACSDMDVASEYTHYDEKKPSPSH-----------------SAASASQGLKGESSSsPISLPTPQNPPKEASQAHPGFHFHSIPKPASLSQTPMHSALPSFVPFSPSGPPLLGCCETPMVSLAEAQQELQMLQKQLGESVSIAPPASTSTLLSNQTEASSPHYINPAQPHTPTRSTIELGRILEPGYLGSSGQWDMMRPQKGSVSGELSSGSSMYQLNSKPTGADLLEEHLGEIRNLRQRLEESICVNDRLREQLQHRLSSTARENGSTSHFYSQGLESMPQLYNENRALREENQSLQTRLSHASRGHSQEVDHLREALLSSRSQLQELEKELEQQKAERQQLLEDLQEKQDEIVQFREERLSLQENNSRLQHKLALLQQQCEEKQQLsLsLQsELQIyESLCENPKKALKAFSLDSCHQVP--GELSCLVAEIRALRGQLEQSIEVNNRLRLQLEQQMDRGAGKASLGPIAVGQSFPDKAEPANLH---QGSAASPPVRDVGLNSPAMVLPNSSCSAPGSDHAIVTRTNNELSSDDSAAMKNPPKLEVDATDGPFANKHGRHVIGHVDDYDALQQQIGEGKLLIQKILSLMRSARSIPGQEAQDTEAPGNIsAHELRSSAKALNHALEESTSLLNMFWRAALPNTHGPVLVGKEGQLMEKELLDLRAQVSQQEQILQNTAARLKRANQRKKSMEQFIVSHLTRTHDVLKKARTNLE-----------MKSFRALTCTP-----AL
PDE4DIP rat	-----------------------------------------------------------------------------------------------------------------------------------------MSNGYRTLSQHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEVSREDVYKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDRKQHLHKTWADEEDLNSQNEAELRRQVEEP--------------------QQETEHVYELLDNNIQLLQEESRFAKDEATQMETLVEAEKGCNLELSERWKDATKNREDAPGDQVKLDQYSAALAQRDRRIEELRQSLAAQEGLVEQLSREKQQLLHLLEEPGGMEVQPMPKGLPTQQKPDLNETPTTQPSVSDSHLAELQDKIQQTEVTNKILQEKLNDMSCELRSAQESSQKQDTTIQSLKEMLKSRESETEELYQVIEGQNDTMAKLPEMLHQSQLGQLQSSEGIAPAQQQVALLDLQSALFCSQLEIQKLQRLLRQKERQLADGKRCMQFVEAAAQEREQQKEAAWKHNQELRKALQHLQGELHSKSQQLHVLEAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDTTDKTLDTNEVFLEKLRQRIQDRAVALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCVLSANEATMQSMESLLRARGLEVEQLIATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLSATLLHKLGPGQSEVAEELCQRLQRKERVLQDLLSDRNKQAMEHEMEVQGLLQSMGTREQERQAVAEKMVQAFMERNSELQALRQYLGGKELMAASQAFISNQPAGATSVGPHHGEQTDQGSTQMPSRDDSTSLTAREEASIPRSTLGDSDTVAGLEKELSNAKEELELMAKKERESQIELSALQSMMAVQEEELQVQAADLESLTRNIQIKEDLIKDLQMQLVDPEDMPAMERLTQEVLLLREKVASVEPQGQEGSENRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPETFERDRTLQVELEGAQVLRSRLEEVLGRSLERLSRLETLAAIGGATAGDETEDTSTQFTDSIEEEAAHNSHQQLIKVSLEKSLTTMETQNTCLQPPSPVGEDGNRHLQEEMLHLRAEIHQPLEEKRKAEAELKELKAQIEEAGFSSVSHI-RNTMLSLCLENAELKEQMGEAMSDGWEVEEDKEKGEVMVETVVAKGGLSEDSLQAEFRKVQGRLKSAYNIINLLKEQLVLRSSEGNTKEMPEFLVRLAREVDRMNMGLP-SSEKHQHQEQEN-MTARPGPRPQSLKLGTALSVDGYQLENKSQAQDSGHQPEFSLPGSTKHLRSQLAQCRQRYQDLQEKLLISEATVFAQANQLEKYRAILS-ESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHGNLKPVVLVEGLCSEQGYLDPVLVSSPVKNPWRTSQ-EARGVQAQGTSDDSSLLRKDIRDLKAQLQNAYKVIQNLRSRVRSLSATSDYSSSLERPRKLRAVATLEGASPHSVTDEDEGLLSDGTGAFYPPGLQAKKNLENLIQRVSQLEAQLPKTGLEGKLAEELKSASWPGKYDSLIQDQARKTVISASENTKREKD----LFSSHPTFERYVKSFEDLLRNNDLTTYLGQSFREQLSSRRSVTDRLTSKFSTKDHKSEKEEAGLEPLALRLSRELQEKEKVIEVLQAKLDTRFSSPPSSHAASDSHRSASSTSFLSDDIEACSDMDVASEYTHYEEKKPSPSN-----------------SAASASQGLKGEPRSSSISLPTPQNPPKEASQAQPGFHFNSIPKPASLSQAPMHFTVPSFMPFGPSGPPLLGCCETPVVSLAEAQQELQMLQKQLGRSVSIAPPTSTSTLLSNHTEASSPRYSNPAQPHSPARGTIELGRILEPGYLG-SGQWDMMRPQKGSISGELSSGSSMYQLNSKPTGADLLEEHLGEIRNLRQRLEESICVNDRLREQLQHRLSSTARENGSTSHFYSQGLESMPQLYNENRALREENQSLQTRLSHASRGHSQEVDHLREALLSSSSQLQELEKELEQQKAERRQLLEDLQEKQDEIVHFREERLSLQENNSRLQHKLALLQQQCEEKQQLSLSLQSELQIYESLYENPKKGLKAFSLDSCYQVP--GELSCLVAEIRALRVQLEQSIQVNNRLRLQLEQQMDHGAGKASLsSCPVNQSFSAKAELANQQPPFQGSAASPPVRDVGLNSPPVVLPSNSCSVPGSDSAIISRTNN--GSDESAATKTPPKMEVDAADGPFASGHGRHVIGHVDDYDALQQQIGEGKLLIQKILSLTRPARSVPALDAQGTEAPGTKSVHELRSSARALNHSLEESASLLTMFWRAALPNSHGSVLVGEEGNLMEKELLDLRAQVSQQQQLLQSTAVRLKTANQRKKSMEQFIVSHLTRTHDVLKKARTNLE-----------MKSFRALMCTP-----AL
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Consensus	MK------IC---------------------------------R------RR-----------------------W-----------------HTA--L--------------------------------------MSNGLRTLSQHL--NDLKKEN----------FSLKLRIYFLEERMQQKYEASREDIYKRNIE---------------------------------------------------------------------------------------LKV--------------------------------------------EVESLKRELQDRKQHLDKTWADVENLNSQNEAELRRQKEER--------------------QQETEHVYELLENKIQLLQEEPRLAKNEAARMAALVEAEKGCNLELSEKLKGATKNREDAPGDQVKPDQYSEALAQRDRRIEELRQSLAAQEGLVEQLSREKQQLLHLLEEPLSMEVQPMPEELLKQQKLNLHETPITQQSVSDSHLAELQDKIQQTEATNKILQEKLNDMSCELKCAQESSQKQDGTIQNLKEMLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQSALFCSQLEIQKLQRLVRQKERQLADAKRCVQFVEAAAQEREQQKEAAWKHNQELRKALQQLQEELQNKSQQLRALEAEKYNEIRTQEQNIQHLNHSLSHKEQLIQELRELLQYRDNSDKTLDANEMLLEKLRQRIQDRAVALERAIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRDVLSANEATMQSMESLLRARGLEVEQLSATCQNLQWLKEELETKFGRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQALEHEMEIQGLLQSMGTREQERQAAAEKLVQALMERNSELQALRQYLGGRDLLM-SQAFISNQQAEVTPTG-HHGEQTDQGSMQIPSRDDSTSLTAREDASIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADLESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVEPQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAQPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGA-AGD-TEDTSTEFTDSIEEEAAHHSHQQL-------SL-T-ETQ--------------------EMLHLRAE-HQHLEEKRKAE-ELKELKAQIEEAGFSSVSHI-RNTMLSLCLENAELKEQMGEAMSDGWE-EEDKEKGEVM-ETVV-K--L-E-SLQAEFRK-QGKLK-A-NIINLLKEQL-L-S-EGNSK--PELLV-L-----R-NT-L--S-GKHQHQE--N--T-RP--RPQSL-LGA---VD--QL-N-SQ--D-G-Q--FSLPGST-HLRSQL-QC-QRYQDLQEKLL-SEATVFAQAN-LEKYR-----ESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHN-L---VLMEGLCSEQG-----L-S----KPLEN---KQEEFR--G-------LRKDI-DLKAQLQNANKVIQNL-SRVRSLS-TSDYSSSLERPRKLRAV-TLEG-SPHSV-DEDEGWLSDGTGAFY-PGLQAKKDLESLIQRVSQLEAQLPK-GLE-KLAEELR-ASWPGKYDSLIQDQARE--LSYLRQKIREGR----L-T-HA--KDTVKSFEDLLRSNDIDYYLGQSFREQLAQG-QLTERLTSKLSTKDHKSEK--AGLEPLALRLSRELQEKEKVIEVLQAKLD-RSL-P-SSHA-SDSHRS-S-TSFLSD--EACSDMD--SEYTHY-EKK-SPSH-----------------S--SASQG-K-ES-S-PISLPTPQN-PKEA-QAH-GFHFHSIPK-ASL-Q-P--SA--SF-PFSP-GP-LLGCCETP-VSLAEAQQELQMLQKQLGES-S--PPAST-TLLSN--EA-S--Y-N-AQPH-P-R-TIELGRILEPGYLG-SG-WD-MRPQKGSVSG-LSSGSS-YQLNSKPTGADLLEEHLGEIRNLRQRLEESIC-NDRLREQL-HRL-STAR--GSTS-FYSQGLES-PQL-NENR-LRE-N--LQ--LSH-SR-HSQE---LREALLSSRS-LQELEKELE-QK-ERQQ------------------------------------------------SLQSELQIYE-L--N-KK-LKA-SLD-CHQ-P----LS-LVAE-RALRGQLEQSI--NN-LRLQL-QQ---GAGKASL-P----Q-FP----P-N-----Q-SA-SPPVRDVG-NSPA-V-P-S--S-PGS---I--R-N-----D-S--MK-PPKLE-DATDG-FANKHGRHVIGH-DDY-AL-QQI-EGKLL--KI-SL-RSA-S-PG-EAQ-TE--G----HELRSS--AL-HALEES-SLL-MFWRAALP-TH-PVL-GK-G---E-ELL-LR--VS-QE--LQ-T---LK-ANQ-K-SMEQFIVS-LTRTHDVLKKARTNLE------------KS-RAL-CTP-----AL