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DTX2 human	MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPyIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYtVNyTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGr R213-m1 R213-m2 Yr R215-m1 R215-m2 HsMTNLPAYPVPQHPPHrTAsVFGTHQAFAPyNk K249-ac K249-ub PsLsGArsAPRLNTTNAWGAAPPSLGSQPLyrSSLSHLGPQHLPPGSSTSGAVSASLPSGP-SSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTsPPAsRLAskSHGsVKRLRkMSVkGAtPKPEPEPEQVIkNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCkTIYGEkTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLk K553-ac K553-ub VAWkRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
DTX2 iso2 human	MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGP-SSSPGSVPATVPMQMPKPSRVQQALA-----------------------------------------------GATPkPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
DTX2 mouse	MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQHFVRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQNTGTMRSVRRHLFSQNSAPGQGIVWEWLGDDGSWVAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHsMtNLPAYPAPQ-APHRTTtVSGAHQAFAPYNKPSLSGARSAPRLNTTNPWAAAPPVAGNQSLFHSSLSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKASRVQQALAGMTSVL-SAIGLPVCLSRAPRPTGPPASRPASKSHSSVKRLRKMSVKEG--APKPEPEQVIRKYTEELKVAPEEDCIICMEKLAVASGYSDMTDSKALGPMVVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFQMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLkVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
DTX2 rat	MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQQFIRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRSVRRHLFSQNSAPGQGIVWEWLGDDGSWIAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHSMTNLPAYPAPQ-APHRTATVSGAHQAFAPYNKPSLSGARSAPRLNTTSPWGATPPVPGNQSLLHSSLSHLGPQLLPSGPSTSSGTSASFPSGPSSSSPGSAPTTVPVQMPKPSRVQQALAGMTSVL-SAIGLPVCLSRAPRPTGPPASRPTSKSHSSVKRLRKMSVKEG--APKPEPEQVIRKYTEELKVAPEEDCIICMEKLSVASGYSDVTDSKALGPMVVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFHMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
	******:**:***:*:::***********:**************:*::*:**:**********************************:*****:******:*:****:*:*****:*****.****::***********:*:**************:*:****************:**:****::**:*:::*::*:*:***:**:*******************:**.:****::*:*:************************::*:*:**::*:*:*.:*********:**:*:***:::***:****.******:*:***:****:********:::::: :::::::::::::.::.:::::..::::.:::::::::::::..:*:*******::*******:*:**********::******:*****:*:::**:*******************************************:*****:**:****************:***********:******************::***********************************************:*******************************
Consensus	MAMAPSPSLPQVYPSHAAVAVWEWQDGLGIWHPYSATVCSFIEQQFVRQRGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQNSAPGRGIVWEWLGDDGSWTAYEARICDYLEQQVARGNQLVDLAPLGYNYTVNYATHTQTNKTSSFCRSVRRQAGPPYPVTSDIAPPRQMGLACFCQQCLHGSRTGPVSGRYRHSMTNLPAYPAPQHAPHRTASVFGAHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGNQPLYRSSLSHLGPQHLPPGPSTSGAVSASLPSGPSSSSPGSAPATVPMQMPKPSRVQQALAGMTSVL-SAIGLPVCLSRAPRPTGPPASRPASKSHSSVKRLRKMSVKEATPAPEPEPEQVIRNYTEELKVAPDEDCIICMEKLSTASGYSDVTDSKAIGPLAVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYNIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ