Multiple Sequence Alignment:
TDP-43	Download MSA

	( 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 )
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TDP-43 human	MsEyIRVtEDENDEPIEIPSEDDGtV--LLSTVTAQFPGACGLrYRNPVsQCMRGVRLVEGILHAPDAGWGNLVYVVNYPkDNKRk K84-ac K84-ub K84-sm MDEtDAs sAVk K95-ac K95-ub K95-sm VKRAVQk K102-ub K102-sm TSDLIVLGLPWk K114-ub K114-sm TtEQDLk K121-ub K121-sm EYFSTFGEVLMVQVkKDLk K140-ac K140-ub TGHSk K145-ac K145-ub K145-sm GFGFVRFtEyETQVk K160-ub K160-sm VMSQRHMIDGRWCDCk K176-ub K176-sm LPNsk K181-m1 K181-ub K181-sm QsQDEPLRSRk K192-ac K192-ub K192-sm VFVGRCTEDMTEDELREFFSQYGDVMDVFIPkPFRAFAFVTFADDQIAQsLCGEDLIIKGIsVHISNAEPk K263-ub K263-sm HNSNRQLERsGrFGGNPGGFGNQGGFGNs rGGGAGLGNNQGsNMGGGMNFGAFsINPAMMAAAQAALQs sWGMMGMLAsQQNQsGPsGNNQNQGNMQREPNQAFGsGNNSYsGsNsGAAIGWGsAsNAGsGsGFNGGFGs sMDs k s sGWGM
TDP-43 iso4 human	MPQMLA-----------------GEIWCMLSTIQ-----------------------------------------------------------------------------------------------------KVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
TDP-43 mouse	MSEYIRVTEDENDEPIEIPSEDDGTV--LLSTVTAQFPGACGLRYRNPVsQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETdASsAVkVKRAVQk t sDLIVLGLPWk K114-ac K114-ub TTEQDLkDYFSTFGEVLMVQVKkDLKTGHSKGFGFVRFTEyETQVkVMSQRHMIDGRWCDCkLPNSkQsPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDkVAQSLCGEDLIIKGISVHISNAEPKHNsNRQLERsGRFGGNPGGFGNQGGFGNs rGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNsGAPLGWGsAsNAGsGsGFNGGFGs sMDSKs sGWGM
TDP-43 rat	MSEYIRVTEDENDEPIEIPSEDDGTV--LLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVyVVNYPKDNKRKMDEADASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSkGFGFVRFTEYETQVKVMSQRHMIDGRWCDCkLPNSkQsPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDkVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
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Consensus	MSEYIRVTEDENDEPIEIPSEDDGTV--LLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTADELRQFFCQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM

Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.

Aligned using MAFFT. Conservation and consensus calculated using von Neumann entropy from PFAAT.