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ADAM8 human	MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPsHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGtTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRY--RADMCGVLQCKGGQQPLGRAICIVD----VCHALTTEDGT-AYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEV---HAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSsPPFPVPVyTRQAPKQV----------------IKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP
ADAM8 mouse	--MLGLWLLSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRALPSHWGQYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEG-QHAMYQAKHLQQKAGTCGVKDTNLN-DLGPRALEIYRAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNHVDKLYQELSFRVVLVGLEIWN-KDKFYISRYANVTLENFLSWREQNLQGQHPHDNVQLITGVDFIGSTVGLAKVSALCSRHSGAVNQDHSKNSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSKIDLESFVTKPQTGCLTNVPDVNRFVGGPVCGNLFVEHGEQCDCGTPQDCQNPCCNATTCQLVKGAECASGTCCHECKVKPAGEVCRLSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCRDLWGPGARVAADSCYTFSIPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFSSNHGVCHALGTGSNIDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSENCSAKCNNHGVCNHKRECHCHKGWAPPNCVQRLADVSDEQAASTSLPVSVVVVLVILVAAMVIVAGIVIYRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPS----ETVSTNQP------PRPIVKPKRPPPAPPGAVSSsPLPVPVyAPKIPNQFRPDPPTKPLPELKPKQVKPTFAPPTPPVKPGTGGTVPGATQGAGEPKVALKVPIQKR---------
ADAM8 rat	--MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQVFTLHLRKNRDLLGSSYTETYSAANGSEVKEQLHEQDHCLYQGHVEGYEGSAASISTCAGLSGFFRVGSTVHLIEPLDADEEG-QHAVYQAKHLEQKAGTCGVSETSLD-KLGPRTLEIYRAQPGNWLKPREIRYVELYVVADSQEFQKLGTREAVRQRVLEVVNHVDKLYRELSFRVVLVGLEIWN-KDKFYISRYANVTLENFLSWREQNLLGRHPHDNVQLITGVDFIGTTVGLAKVSALCSRHSGAVNQDHTRSAIGVASTMAHELGHNLGMNHDENIPGCYCPIPREGGGCIMTESIGSKFPKTFSRCSQVDLESFVTNHQTGCLTNVPDVNRFVGGPVCGNLFVERGEQCDCGTPQDCQNPCCNATTCQLAKGAECAHGACCHECKVKPAGELCRPMKDKCDLEEFCDGQKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCQALWGPGARAASDSCFAFSIPQGCYGSMYPSRINRCGVLFCEGGQKPLERSSCTFSSHHGLCQALQTDSNTNTYEFVLQGTKCEEGKVCMDGNCQDLRVYRSENCSAKCNNHGVCNHKRECHCHAGWAPPYCAQLLADVPGEQAAKS-LPVSVVVVLVILVAAVVIGAGIVIyRKAPKQIQRRSVAPKPTSGLSNPLFYTGDSSLPAKSRPPDPP----EMVSTNQP------PRPIVKPKRPPPAPPGAMSSPPLPVPVYAPKAPNQLRPDPPTKPLPKLKPKQVKPTFAPPTPPVKPGTGGTVPGVTQGAGGSKVALKVPIQKR---------
	..:******:::::**:**::*:::::*****:*:**:::*:**:***::*::**::**:**:::::**************:*****:*******:**:.:****:********::****:******:***:***::*******:::**.:**:***:**.*:******::::*...****:::::*::*:::*.:**:********:*::***:**:::***:*************::*:************.:*:*::*::::*****:*:*:::::.::*:************:*:***:*:***:**::********:::::***:*****:******.***:::**:*::::*:*:***::****:**:.**:**:::****::.:*::**:*:**::::************:*******:*:**:*:***:*****::**:**:*:**:*********:**:.**:*********::*:*******:*****:****::*:********:::****:::*::**::::*::**.:::*..*:::**:*.*:***:**:*:.*::::.:::*:**.*.:::.::*.*::**:*:::***::*.****:****:****:*:********:*****:*****.*:::*::*..::**:.:***:******:*:::.*:.***::****:.:*::*:****:::*:*****::::*::***.::*:*:....*.*:*::*......*:::*::********:::**:*:*****::::*:*.::::::::::.::::::*******:******:*:::**:::**:::*****:***::.........
Consensus	--MLGLWLLSALWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRALPSHWGLYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLREQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEG-QHAVYQAKHLQQKAGTCGVSDTSLN-DLGPRTLEIYRAQPGNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNHVDKLYQELSFRVVLVGLEIWN-KDKFYISRYANVTLENFLSWREQNLQGRHPHDNVQLITGVDFIGTTVGLAKVSALCSRHSGAVNQDHSKNAIGVASTMAHELGHNLGMNHDENIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSQADLESFVTRPQTGCLTNVPDVNRFVGGPVCGNLFVERGEQCDCGTPQDCQNPCCNATTCQLAKGAECAHGTCCHECKVKPAGELCRPKKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCQALWGPGARAAADSCFAFSIPPGCNGSMYPGRINRCGVLQCEGGQKPLERSICTFSSNHGVCHALQTDSNTNTYELVLQGTKCEEGKVCMDGRCQDLRVYRSENCSAKCNNHGVCNHKRECHCHAGWAPPNCAQLLADVPDEQAASGSLPVSVVVVLVILVAALVIGAGIVIYRKAPRQIQRRSVAPKPTSGLSNPLFYTADSSLPAKNRPPDPS----ELVSTNQP------PRPIVKPKRPPPAPPGAVSSPPLPVPVYAPKAPNQLRPDPPTKPLPELKPKQVKPTFAPPTPPVKPGTGGTVPGATQGAGGPKVALKVPIQKR---------