Multiple Sequence Alignment:
SMN Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290      )
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SMN human MAMssGGsGGGVPEQEDsVLFRrGtGQsDDsDIWDDtALIkAyDk
AVAsFk
HALk
NGDICETsGkPKttPKRKPAKKNKsQKkNtAAsLQQWkVGDKCSAIWSEDGCIyPATIASIDFkRETCVVVyTGyGNREEQNLSDLLSPICEVANNIEQNAQENENESQVsTDESENSR-SPGNksDNIkPksAPWNsFLPPPPPMPGPrLGPGkPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGR-CSHSLN
SMN iso3 human MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSR-SPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMEMLA-------------
SMN mouse --MAMGs-GGAGsEQEDtVLFRRGtGQsDDsDIWDDtALIKAYDKAVASFKHALKNGDICEtPDKPKGTARRKPAKKNKSQKKNATTPLKQWKVGDKCSAVWSEDGCIYPATITSIDFKRETCVVVYTGYGNREEQNLSDLLSPTCEVANSTEQNTQEN--ESQVSTDDSEHSS-RSLRSKAHSKSKAAPWTSFLPPPPPMPGSGLGPGkPGLKFNGPPPPPPLPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQNKKEGK-CSHTN-
SMN rat --MAMGsGGGAGsEQEDTVLFRRGtGQsDDsDIWDDtALIKAYDKAVASFKHALKNGDMCETSDKPKGTARRKPAKKNKNQKKNATAPLKQWKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGYGNKEEQNLSDLLSPTCEVANNTEQNTQEN--ESQVSTDDSEHSS-RSLRSKAHSKSKAAPWTSFLPPPPPVPGAGLGPGKPGLrFSGPPPPPP-PPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQNKKEGKKCSHTN-
SMN cow ----MGGGGGGFPEPEDSVLFRRGTGESDDSDVWDDTALIKAYDKAVASFKHALKNGDISEASEKPKGTPKRKSA-KNKSQRKNTtSPSKQWKVGDNCCAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPTSEVA-NIEQNAQENENESQISTDESENSSRSPLNKPNNIRSRAAPWNSFLPPPPHMPRSGLGPGKSGLNFSGPPPPPP-PPPHFLSRWLPPFPAGPPMIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQSQKEGRYSHFN--
  ..:::*:.**:.:*:**:********:*****:*************************::*::.***:*::**:*:***:*:**::::::***:**:*:*:******:*****:*:*:**************:***********::***:::***:***..***:***:**:*: :::::.:::::::***:*******::*:::*****:**:*:*******.***::*::*:****:***:*******:**:***:*********************::::..:::. ..... 
Consensus --MAMGGGGGGGPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSDKPKGTPKRKPAKKNKSQKKNTTAPLKQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPTCEVANNIEQNAQENENESQVSTDESENSS-SPLNKKANIKSKAAPWNSFLPPPPPMPGPGLGPGKPGLKFNGPPPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGR-CSHTN-
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.