Multiple Sequence Alignment:
LEDGF Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530)
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LEDGF human MTRDFkPGDLIFAkMkGyPHWPARVDEVPDGAVkPPTNKLPIFFFGTHETAFLGPKDIFPYsENkEKYGKPNKRk
GFNEGLWEIDNNPkVkFssQQAAtkQsNAssDVEVEEKEtsVsKEDtDHEEKAsNEDVTkAVDIttPkAARRGRKRKAEKQVEtEEAGVVttAtAsVNLKVsPKRGRPAAtEVKIPKPRGRPKMVk
QPCPsEsDIItEEDkSKKkGQEEkQPkkQPkKDEEGQKEEDKPRKEPDkKEGkKEVESKRKNLAKtGVtstsDsEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMEtEQQNKDEGKKPEVKKVEKKREtsMDsRLQRIHAEIkNSLk
IDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLkKIRRFkVSQVIMEkSTMLYNkFkNMFLVGEGDsVItQVLNksLAEQRQHEEANKTKDQGkkGPNkKLEKEQTGSKTLNGGsDAQDGNQPQHNGEsNEDsKDNHEASTKKKPssEEREtEIsLkDstLDN
LEDGF iso2 human MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRkGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDkKEGkKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEHQTTCNLQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
LEDGF mouse MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPkDIFPYSENk
EKYGKPNKRKGFNEGLWEIDNNPKVKFSsQQASTKQsNAssDVEVEEKEtNVsKEDtDQEEKAsNEDVtKAVDIttPKAARRGRKRKAEKQVDtEEAGMVtAATA-SNVKAsPKRGRPAATEVKIPKPRGRPKVVKQPCPsDGDMVIDEDKSKKKGPEEKQPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVtstsDsED-EDDQEGEKKRKGGRNFQAAHRRNMLkGQHEKEAGDRKRKQEEQMETEQQNKDEGKKPEVKKVEKKREtSMDSRLQRIHAEIKNSLkIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFkNMFLVGEGDSVITQVLNksLAEQRQHEEANKTKDQGKKGPNKKLEKEPTGTKSLNGGSDAQESNHPQHNGDSNEDGKDSREASSKTKPPGEEREAEIsLkESTLDN
LEDGF rat MTRDFkPGDLIFAKMkGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVkFSSQQVSTkQsNAssDVEAEEKETSVSKEDtDQEEKAsNEDVTKAADITtPKAARRGRKRKAEkQVDtEEAGVVTAATA-SNVKAsPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKKKGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVtstsDsEE-DDDQEGEKKRKGGRHFQAAHRRNMLkGQHEKEAADRKRKQEEQMETEQQTKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGTKSLNGGSDAQESNHPQHNGDsAEESKDSREAGSKTKTPGEEREAEVSLKESTLDN
  ************************************************************************************************::***********:*****:*******:************:********************:*****:**:***.:*:*:**********************:*******::*::::********:***:****:**:*******:************************:*********:..*************:**:***************:*************:*::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::.:.::::::::..:.:::::.:::..::..::..:.:...::::.:.:::.:::::
Consensus MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDQEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVDTEEAGVVTAATASSNLKASPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIIIDEDKSKKKGQEEKQPKKQLKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEEEGDDQEGEKKRKGGRNFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGTKSLNGGSDAQESNHPQHNGDSNEDSKDSREASSKTKPPGEEREAEISLKESTLDN
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.