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ASE-1 human	MEEPQAG--DAARFSCPPNFTAKPPASEsPRFSLEALTGPDTELWLIQAPADFAPECFNGRHVPLSGsQIVkGKLAGKRHRyRVLSSCP--QAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQsL-SGsPLQPIPAsPPPQIPPGLRPRFCAFGGNPPVtGPr R162-m1 R162-m2 sALAPNLLtsGkKKKEMQVTE-APVTQEAVNGHGALEVDMALGsPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKE--TFEPE-------DKTV--KQEQINtEPLEDtVLsPtKKRKRQKGTEGMEPEEGVTVEsQPQVkVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLEsPGGtMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVV-------GPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPI--------QPLEPELPGEGQPEARAtPGsTKKRKKQSQESRMPEtVPQEEMPGPPLNsEsGEEAPTGRDKKRKQQQQQPV-
ASE-1 iso2 human	MEEPQAGGEDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRHVPLSGSQIVKGKLAGKRHRYRVLSSCP--QAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSL-SGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQVTE-APVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKKRKKPKGKE--TFEPE-------DKTV--KQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVV-------GPELPDDLEPQAAPTSTKKKKKKKERGHTVTEPI--------QPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQPV-
ASE-1 mouse	--MAGTQACSATRFSCPPHFTEMSPDSEPSRFSLEALTGPDTELWLIQAPADFAPQCLNGRRVPLSGsKtVKGKLDGKKHRYRVFTSsP--QAREATLLASSSEAGGRLTCAPAPSGSLRIMEGPQEyLLSRVPLQLIPTSLPPQIPAGLRPRFSAFGGsPPVTGPGsAsALRsPtsGKRKSTRKGTDASsDTQEAVNRHGAMEVKTALGNLGVSVKKR-KRYFMQ----EEMEAKTMEPV---AELP-VPSAtSSKKRKKSKGTETSQV--------------EHTEPVAQTEPPEGTFLFPTKKRKRQKEADGTEEVDGIVADSQPQVIVEAQEETILLSPTKKRRKEKRQNLGMEAEMGP-------------PGVLMVTEHS-EHGLQAEVALVSPKKTKKKKGKR-V-------------GETEAALPDDFEPQGALAPS----KKKERGARL-------------------------------------------------------------------------------------
ASE-1 rat	--MEGTSACGATRFSCPPHFTAMSPDSDPPRFSLEALTGPDTEVWLIRAPADFAPQCLNGRRVPLSGSKTVKGKLDGKKHRYRVVTSGP--QAGEATLLMSSMEAGGRLACAPAPNGSLRIMEGPQEYLISRVPLQPIPTSLPPQIPAGLRPRFSAFGGSPPVTGPGSASVLRSPTSGKRKKKRKDAE-ASDTQEAVNRHEAMKVETAWGDLGMDVKKKRKRHHVD----EEAEAKGMEPLAELAELP-VPSATGSKKRKKSKGAETLQAEED----------PGHMEPVAQTEPPEGPFLSPTKKRKRQKQAEGAEEVDGTMADSQPQVTVEPHEETILLSPTKKRKKEKRQNLVMEAEMGL-------------PGVLMETELL-EPGLQAEVAPVSPKKTKKKKKGKCVD-----EALALAAEVTEAALPADFEPQGAPVPS----KKKERGQKATEPGSEVTDPRQS---------EEPEPRAGQGSPKKKKKKDQESRVQNTIPH---------------------------------
ASE-1 cow	--MAGTPSGSAARFSCPPNFTATPPASEHSRFSLEALTGPDTELWLIQAPVDFAPDCLNGRLVPLSGSQIVKGKLAGKRHRYRVLSSSGPRAGGEATLLAPSAEAGGGLTCALAPQGSLRIFESPQESL-TGTLLQSIPASPPPQIPPGLRPRFCAFGGsPPVTGPGSVLALKSLASGKRKKKRHLPE-ASVPQEAVNEHGALEVDTALGSLELDVGKKE--KKHQLKELEATEPLATEPVAEMLEPPGTLSPSTTRKRKKKPKESVEMVKPETGMPESKEKTVEELEFRVKREPLEETVLSPRKKRKKQKEPGEMEPVEGTTVESQLQVKTEPQEEAIPLPSSKKKKKEKRYKGMREPGMEVM---EPEVKPLELTGEVMEPDLPPDVQAQSEAALGSPKKRRKKEKQQNVMMQPGTEVVEPQAEGMEPELPGAAEPQAALASTKK--KKKERGHLATEPGTEMTNPQGEMMEPELPDEGQPEARADPASTKKRKKQGQKSQVPETAPQEEMPEPPLNPESGQVAPKGQERKRKKKPQQDPM
	..::::....*:******:**:.:*:*:.:*************:***:**:****.*:***.******::*****:**:*****::*.:  :::*****::*:****:*:**.**:*:***.*:**::* ::.:**:**:*:*****:******:****:******:*::::.:::***:*:.:..:: ::::*****.*:*::*::*:*:::::*.*:.:.:..:....*::::.::**.::.:*::.::::::::****.::::...:...       .......:..:.:**:*.::*:*:****:**.::::*:::*.:::**:**::*:.**:*:*:::**::***::.:::*:::::.............:*..*::..:..:.:*:::*:::***..**::::.:......::.. .....:::**:::***:*::::....******:.::::. . . .  ............:::::..::.::.::..:.:....:.:.................................
Consensus	--MAGTGACDAARFSCPPNFTAKPPASEPPRFSLEALTGPDTELWLIQAPADFAPQCLNGRRVPLSGSQIVKGKLAGKRHRYRVLSSCP--QAGEATLLAPSTEAGGGLTCAPAPQGSLRILEGPQESL-SGSPLQPIPASPPPQIPPGLRPRFCAFGGSPPVTGPGSALALRSLTSGKRKKERQVTE-ASVTQEAVNRHGALEVDTALGSLEMDVRKKKKRKNQQLKEPEAAEPKGTEPTAETLEPPGVLSPSTTKKRKKPKGKET-QFEPE-------DKTVEHKEEQANTEPLEDTVLSPTKKRKRQKEAEGMEPVEGTTVESQPQVKVEPQEEAIPLPPTKKRKKEKRQNAMMEPGMEAM---EPEMKPLESPGGLMAPQQPEEAGLQAEAALASPKKKKKKEKQQDVTVEPETEVV----E-TEPELPDDLEPQAAPASTKK--KKKERGHTATEPG--------QPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEEMPGPPLNSESGEEAPTGRDKKRKQQQQQPV-