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PNN human	MAVAVRTLQEQLEKAKESLKNVDENIRkLTGRDPNDVRPIQArLLALsGPGGGr R54-m1 R54-m2 Gr R56-m1 R56-m2 GsLLLr R62-m1 R62-m2 rGFsDsGGGPPAKQRDLEGAVsRLGGERRtRREsRQEsDPEDDDVKk K109-ub K109-sm PALQssVVATskERtRRDLIQDQNMDEkGKQRNRRIFGLLMGtLQKFk K157-m1 K157-ub K157-sm QEsTVAtERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQkVELAQLQEEWNEHNAkIIKYIRTKTk K238-ac K238-ub PHLFyIPGRMCPATQKLIEESQRkMNALFEGRRIEFAEQINkMEARPRRQsMKEKEHQ-VVRNEEQkAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHsDAEKEQEEEEQKQEMEVKMEEETEVREsEKQQDsQPEEVMDVLEMVENVKHVIADQEVMEtNRVEsVEPsENEAsKELEPEMEFEIEPDKECKtLsPGKENVsALDMEKEsEEKEEKES---EPQPEPVAQPQ------PQ----SQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERkDFPVESVkLTEVPVEPVLtVHPEskSKTKtRsRSRGRARNKTSKSRsRSssssssSSSsTsssSGsSSsSGssssrsSSSSSsSTSGSSsRDsSssTSSSsESRsRSRGRGHNRDRKHRRsVDRKRRDtsGLERsHKsskGGssRDTKGSKDKNSRSDRKRsIsEssRsGKRSsRsERDRKSDRKDKRR
PNN mouse	MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALsGPGGGr R54-m1 R54-m2 Gr R56-m1 R56-m2 GsLLLRRGFsDsGGGPPAKQRDLEGAVsRLGGERRtRREsRQEsDPEDDDVKKPALQSSVVATsKERT-RDLIQDQNMDEkGkQRNRRIFGLLMGTLQkFKQEsTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQsMKEKEHQ-VVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEVEEAGEEEEKEAGIVHsDAEKEQEEEEQKQEMEVKtEEEAEVREGEKQQDsQPEEVMDVLEMVESVKHVIAEQEVMETNQVEsIEPSENETSKELEPEMEFDVEPDKECKsLsPGKENINsQEVEKEsEEKEEKEEKEPEPQPEPVAQPQPPPQPLPQ----SQPHSQPHSQPQPVLQSQPLCQPETLPLAVLQPPPQVIQEQGNLLPERKDFPLESIKLPEVSVEPVLTVHsENKSKNKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSMDRKRRDtsGLERSHKSSKGGsSRDRKGSKDKSSRPDRKRsIsEssRSGKRSSRSERDRKSDRKDKRR
PNN rat	MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGrGrGSLLLRRGFsDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQEsDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQ-VVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAG-EEEKEAGVVHsDAEKDQEEEEQKQETEARMEEETGVREGEKQQDsQPEEVMDVLEMVESVKNVIAEQEVMETNQVESIEPSENETSKELEPEMEFDVEPDKECKsLsPGKENINsLEVEKESEEKEEKEDKEPEPQPEPVAQPQPPPQPLPQSQPHSQPHSQPHSQPQPALQSQPLSQPEALPLAVLQPPPQVIQEQGNLPPERKDFPVEAIKLPEVPVEPVLTVHSENKSKNKTRSRSRGRARNKTSKSRsRsSssSSSSSssTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSSSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTsGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRsISESSRSGKRSSRSERDRKSDRKDKRR
PNN cow	MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFsDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVVRNEEQKSEQEEGKVAQREEELEETGNQHNDVEIEEAGEDEEKEIGIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVESVKNVIAEQEVMEINQVESIEPSENETSKELEPEMEFEVEPDKECKSVSPAKENASTLEMENEPEEKEEKES---EPQPEPMAQPQSLPQPQPQ----SQ--SQSQSQPQQVLQPPPLSQPETLPLAVSQPPPQVIQEQGHLPPERKEFLVESVKLTEV-TEPVLTVHSESKNKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTTSSSESRSRSRGRGHNRDRKHRRSVDRKRRDASGLERSHKSAKGGSSRDAKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR
	******:*********************************************************************************************************************:*************************************************************************************************************************************************************************** ********:*************************:****::****:::*******:*********:*:::***::***:*******************:**:***:*****:*:***:******:**********::*******::**:***::::::*:*:*******....******:****..:::.**    **:.:*.:**:*::**::*::***:*:***:**:***:****:*:****:*::*::**:**.:*******:*:*:*:********************************************************************::***********************:******:*********:*******:******:**:********************************
Consensus	MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQ-VVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEAGIVHSDAEKEQEEEEQKQEMEVKMEEETEVREGEKQQDSQPEEVMDVLEMVESVKNVIAEQEVMETNQVESIEPSENETSKELEPEMEFDVEPDKECKSLSPGKENINSLEMEKESEEKEEKESKEPEPQPEPVAQPQPPPQPLPQ----SQPHSQPQSQPQPVLQSQPLSQPETLPLAVLQPPPQVIQEQGNLLPERKDFPVESIKLPEVPVEPVLTVHSENKSKNKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR