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PIMT human	MCCEkWSRVAEMFLFIEERE-DCKILCLCSRAFVEDRkLyNLGLkGYYIRDsGNNsGDQAtEEEEGGySCGtAESHDSKGIGLDEsELDsEAELMRsMGLPLQFGRITAHkDFEVSMNTRNkVKI--KKKKHQKkYLDEIVQEsWRkEyEEDDILAsDDPSSIEQYENTRTYELQSkkDtEtENPPVENTLsPkLEITEkWEKyWNEYGGGLLWQSWQEKHPGQALSSEPWNFPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFDASQSCDTDTYTSKTEADDKNDEKCMKVDLVsFPssPIMVDNDsSGTSDKDHsEILDGISNIKLNSEEVTQSQLDSCTSHDGHQQLSEVSSKRECPASGQSEPRNGGTNEESNSSGNTNTDPPAEDsQKSSGANTSKDRPHAsGtDGDEsEEDPPEHKPsKLKRSHELDIDENPAsDFDDSGsLLGFkYGSGQkYGGIPNFSHRQVRYLEkNVKLKSkyLDMRRQIKMKNkHIFFTkESEKPFF-KKSKILSk K514-ub K514-sm VEKFLTWVNKPMDEEASQESSSHDNVHDASTSSDSEEQDMSVKkGDDLLETNNPEPEKCQSVSsAGELETENYERDSLLATVPDEQDCVTQEVPDSRQAEtEAEVKKKK---NKKKNKKVNGLPPEIAAVPELAkYWAQRYRLFsRFDDGIkLDREGWFSVTPEkIAEHIAGRVSQSFKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVkIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNkLkTITAYFGDLIRRPAsET--------
PIMT mouse	MCCEKWNHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDQGtEEEEDGHSNGtAESHSP-----NESDLDSEAKLMRSMGLPIQFGRMSsHENFEMSMNARNKAKVKQKRRKHQKRYLDEMVRESWRNDYEEDDLVVsDDPSSVEHCENNRTCEIQSKAGsEVENLPVENTLAPKLEVPENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFTASQNCDKDVYTSHTEVDQ-NAESSLKADVMTFSSSPNIVEDEIPGSNDNDHNEIITAINNITVSAEKVEQSQLDSsQHCDE--PLSEI-TGKECPASGGSDSCNGTP-KENDISENRSSDQPAKELQESSGTNKGKHRPHHNGADGHEsDDDPPEHKPSKVKRSHELDVDENPDsEVDDNGFLLGFKHGSGQKYGGIPNFSHRQVRYLEKNVKYKSKYLDLRKQMPVKSKHILFTEDSGKPFVVCKSKVRSKVEKFLKWVNERVDEETsQDSLSQNKMQDTCTSSDSEEQDMSLEKADNLMETRDPEPEKCQIISSATELEAEKSEVGSLVATVPE--NCSTEEIPNsPHAEtEVEIKKKK---KKNKNKKINDLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQAFRCDVVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADIDQVASLAGLGGQVEIEQNFLNNKLKTITAYFGDLIRRPALLKTSTSEAEV
PIMT rat	MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDRVTEEEEDDHSSGTTESHSA-----DEGDLDPEAKLMRSMGLPVRFGRMSTHGSFEVSMNARNKAKVRQKRRKHRKQYLDEIVREDWRNDCEEDDLVVSDDPSSVEHCENNSACEIQSKTDAEAENLPVENTLAPKLEVTENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFVASQNCDKDVCTSHTQVDQ-NAESSLKADGTTLSSsPNTAEDESLGSNDNDHNEIIAGINKITLSAEEVEQSQLDSSEHCDK--PLSEV-TGKECPASGGSDSCHGTP-KESDISENRSSDQPAQELQESSGTNTSKHRPHHNGTDGNESEDDPPDHKPSKMKRSHELDIDENPDsEVDDNGFHLGFKHGSGQKYGGIPNFSRRQVRYLEKNVKYKSKYLDMRKRMTVKNKHIVFSEESGKPFI-RKSKVRSKVEKFLKWVNEPVDEEIsQEPLSHNKMQDTCTSSDSEEQDMSMEKTDGLMETRDPEPENCQTISSASELEAEKSEGGSLVAAVPE--NCSTEGVANSPRAEAEVEIKKKKKKKKKNKNKKINGLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQSFNCDIIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGVADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADVDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPALRSAEA-----
	******::****:****:**:::*************************:::****:**::*****:::*.**:***::.....:*::**:**:********.:***:::*..**:***:***:*:.:*::**:*.****:*:*:**:::****:::******:*::**::::*:***:::*:**:******:****::*:*********:**********:*:*:*******:********************************.***:**:*::**:*::*:.*:*:::*:*..:::***:.:::::.*::*:**:**:::*::*::::*:*:******:.::*...:***:.:::******:*::::*::.:*:::*:*:::*:**.::*:***:*::*:***::*:**.**::***:*****.*******:****:*::**:*::****:*************:***********:******:*:::.:*:***.*:::*:***...***::*******:***:::***:**:::*:::::*::***********.:*:*.*:**::****:**.:***.***:*::*.:**:*:**:..:*:*:::::*:.**:*:*:****...:*:****:*:******:*************************:*********************:*.**::******************:************:**********:***************::****************************************:***************:********:******************************:..........
Consensus	MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDQATEEEEDGHSNGTAESHSA-----DESDLDSEAKLMRSMGLPIQFGRMSAHENFEVSMNARNKAKVRQKRRKHQKRYLDEIVRESWRNDYEEDDLVVSDDPSSVEHCENNRTCEIQSKADAEAENLPVENTLAPKLEVTENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFDASQNCDKDVYTSHTEVDQ-NAESSLKADGMTFSSSPNIVEDESLGSNDNDHNEIIAGINNITLSAEEVEQSQLDSSQHCDE--PLSEV-TGKECPASGGSDSCNGTP-KESDISENRSSDQPAQELQESSGTNTSKHRPHHNGTDGNESEDDPPEHKPSKLKRSHELDIDENPDSEVDDNGFLLGFKHGSGQKYGGIPNFSHRQVRYLEKNVKYKSKYLDMRKQMKVKNKHILFTEESGKPFI-RKSKVRSKVEKFLKWVNEPVDEEASQESLSHNKMQDTCTSSDSEEQDMSLEKADNLMETRDPEPEKCQIISSAGELEAEKSERGSLVATVPE--NCSTEEVPNSPRAETEVEIKKKK---KKNKNKKINGLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQSFRCDVVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPALRKAEA-----