Multiple Sequence Alignment:
IWS1 Download MSA
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IWS1 human MDSEYYsGDQs-DDGGAtPVQDERDsGsDGEDDVNEQHSGsDTGsVERHsENETsDREDGLPKGHHVtDsENDEPLNLNAsDsEsEELHRQKDsDsEsEERAEPPAsDsENEDVNQHGsDsEsEETRKLPGsDsENEELLNGHAsDsENEDVGKHPAsDsEIEELQKsPAsDsETEDALKPQIsDSESEEPPRHQAsDsENEEPPKPRMsDsEsEELPKPQVsDsE-SEEPPRHQAsDsENEELPKPRIsDsEsEDPPRHQAsDsENEELPKPRIsDsEsEDPPRNQAsDsENEELPKPRVsDsEsEGPQKGPAsDsEtEDAsRHKQKPEsDDDsDRENKGEDtEMQNDsFHsDSHMDRKKFHssDsEEEEHKKQKMDsDED-EKEGEEEKVAKRKAAVLsDsEDE-EKAsAkKsRVVsDADDsDsDAVsDKsGKREktIAsDsEEEAGKELs-DKKNEEKDLFGSDSESGNEEENLIADIFGEsGDEEEEEFTGFNQEDLEEEKGETQVKEAEDsDsDDNIkRGkHMDFLsDFEMMLQRKKSMSGKRRRNRDGGTFIsDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLtLLPAVVMHLKkQDLkETFIDSGVMSAIKEWLsPLPDrSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNstGGQtPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDyVVRPkWNVEMESSRFQATSKkGISRLDKQMRkFTDIRKKSRSAHAVKISIEGNkMPL
IWS1 iso2 human ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSEYYSGDQSDDGGATPVQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDED-EKEGEEEKVAKRKAAVLSDSEDE-EKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELS-DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
IWS1 iso3 human MDSEYYSGDQS-DDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDED-EKEGEEEKVAKRKAAVLSDSEDE-EKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELS-DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
IWS1 mouse MDSEYYSGDQS-DDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDS-------------ENEELLNGHASDSEKEEVSKHAAS-------------DSEAEDTLQPQVSESDSEDPPRPQAsDsENEEPPKPRIsDsEsEELPK---------------------------PRVsDsEsEDPPRPQAsDsEsEELPKPRVsDsEsEDPPRPQAsDsEsEELPKPRVsDsEsEDPQKGPAsDsEAEDASRHKEKPDsD-DsDGENKREDsEVQNE---SDGHtDRKGLHssDsEEEEPKrQKIDsDDDEEKEGDEEKVAKRKAAVLsDsEDDAGNAsAKKSRVVCDADDsDsDVVsDKsGKREttVAsDsEEEAGKEESsVkKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDsDsDDNIKRGKHMDFLsDFEMMLQRKKSMCGKRRRNRDGGTFIsDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNkDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRLsstGGQtPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQASSKKGISRLDKQMRKFtDIRKKSRSAHAVKISIEGNKMPL
IWS1 rat MDSEYYSGDQS-DDGGATPVQDERDSGsDGEDDVNEQHSGSDTGSVDRHSENETSDREDGLTKIHNGTDSENDEPSNVHASDSESEELHRPKDSDSESEEHAESPASDSENEAVHQQGSDS-------------EKEELLNGHAsDsEKEEGRKHAAS-------------DSETEDTLQPQGSESDSEDPPRPQASDSESEEPPKPRIsDsEsEELPK---------------------------PRIsDSESEDPPRPQVSDSESEELPKPRVsDSESEDPPRPQASDSESEELPKPRVsDSESEDPQKGPAsDsEAEDASRHKEKPESE-DSDGENKREDsEVQNE---SDGHADRKGLHssDsEEEEPKRQKIDsDDDGEKEGDE-KVAKRKAAVLsDsEDEDKASAAKKSRVIsDADDsDsDVVsDKSGKREKtVAsDsEEEVGKEESSVKKSEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDsDsDDNIKRGKHMDFLSDFEMMLQRKKSMCGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMsStGGQtPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRPG-ILKKGLSRLEKHKRRFAEQKRLSQMHRAVKFsIEGNRMPL
IWS1 cow MDSEYYSGDQSADDGGATPVQDERDSGSDVEDDVNEQHSGSDTGSVERHSENEPSDREDSLNKRHQVTDSDNDDPSNLNASDSESEELQRQKDSDSESEEHAEPPASDSENEDVNHHGSDSESEETRKLPASDSENEELLNGHASDSENEDVRKPPASDSEVEELPKSPASDSETEGAPKPQASDSESEEPPRNQASDSENEELPKPRISDSESEELPKPRISDSEKSEDPPRQQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEEPQKGPASDSETEDASRHKQKPESEEDSDGENKGEDTEVQNDSLPADAHVDRKRFNSSDSEEEEPKRAKIDSDEDEEKEGEEEKVAKRKAAVLSDSDDE-EKASAKKSRVVSDADDSDSDVISDKSGKREKTIASDSDEEAGKELS-DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKSETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLRILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNsTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQGTSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
  ::::::::::: ::::::::::::::::::::::::::::::::::.::::::::::::.:.:.:..:::.::.:.:..:::::::::.:.:::::.:::.::.::::::::.:...::::......... ...:.::::::::::::.:...:..::... ... .....:::.:....::.:.:.::.:::.::::::.::.::::.::::::::::.  .... .. ... ............::.::::::::::.:.::::.:::::::.::::::::::.::::::.::::::::::::::.::::::::::::::::::.:::::.::*::::::::::**::..:*:*:***:::********:*::*:***:*.****:*:*************:*: ::::******::********::********:*:****:**:***:*.:**:*:*********************************************:***:**********************************:****************************************************:*********************************************:******************************************************************************::*********************************************************:::::***:***:*::*:*::::::*::::***:*****:***
Consensus MDSEYYSGDQS-DDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL-KIHNGTDSENDEPSNLNASDSESEELHRQKDSDSESEEHAEPPASDSENEDVNQHGSDS-------------ENEELLNGHASDSENEDVRKHAAS-------------DSETEDALQPQ-SDSDSEDPPRPQASDSENEEPPKPRISDSESEELPK---------------------------PRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEDPQKGPASDSETEDASRHKQKPESDDDSDGENKGEDTEVQNDSFHSDSHMDRKKFHSSDSEEEEHKRQKIDSDED-EKEGEEEKVAKRKAAVLSDSEDE-EKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELS-DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.